ArticleiScience2023
Atypical B cells consist of subsets with distinct functional profiles.
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Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Human CD21Journal of human immunity · 2026Review
- Atypical B cells and inflammatory profiles delineate immunity to influenza vaccination in First Nations and non-Indigenous people with chronic multimorbidity.Nature communications · 2026Article
- MaRNAV-1, an intracellular virus ofbioRxiv : the preprint server for biology · 2026Article
- Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19.JCI insight · 2026Article
- Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.Journal for immunotherapy of cancer · 2026Review
- The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost.Science translational medicine · 2026Article
- Robust effector memory features of human T-betiScience · 2026Article
- CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes.Diabetologia · 2026Article
- Single-cell multi-omics reveals circulating B cell heterogeneity across diverse disease contexts.Frontiers in cell and developmental biology · 2026Article
- Multifaceted B cell response to transient HIV viremia in elite controllers.PLoS pathogens · 2026Article
- Effect of repeated sprint exercise on immunological responses in adult and adolescent athletes at different stages of biological maturation: a-quasi-experimental-trial.Scientific reports · 2025Article
- Article
- Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity.Journal of translational medicine · 2025Article
- Polarization of the memory B-cell response.Journal of leukocyte biology · 2025Review
- Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants.PLoS pathogens · 2025Article
- Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.PLoS pathogens · 2024Article
- Polarization toward Tfh2 cell involved in development of MBC and antibody responses against Plasmodium vivax infection.PLoS neglected tropical diseases · 2024Article
- A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors.Science advances · 2024Article
- Differences in phenotype between long-lived memory B cells againstbioRxiv : the preprint server for biology · 2024Article
- Atypical memory B cells increase in the peripheral blood of patients with breast cancer regardless of lymph node involvement.BMC immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Raphael A ReyesDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Gayani BatugedaraDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Paramita DuttaCenters for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ashley B ReersDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Rolando GarzaDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Isaac SsewanyanaInfectious Disease Research Collaboration, Kampala, Uganda.
Prasanna JagannathanDepartment of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.
Margaret E FeeneyDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Bryan GreenhouseDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.
Sebastiaan BolDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Ferhat AyCenters for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Evelien M BunnikDepartment of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · USLa Jolla Institute for Immunology · USUniversity of California, San Francisco · USLondon School of Hygiene & Tropical Medicine · GBStanford University · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MTransmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3MThe role of γδ T cells in fetal and infant immune defense against malariaR01AI093615 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEENEY, MARGARET E · 2011 to 2025
$9.1MComputational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4MStudying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6MDefining conserved epitopes on polymorphic malaria antigensR01AI153425 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BUNNIK, EVELIEN MARGARETHA · 2021 to 2025
$2.7MMentoring Translational Researchers for Careers in Pediatric Global HealthK24AI113002 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEENEY, MARGARET E · 2014 to 2023
$1.9MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MMentoring translational scientists in international infectious disease researchK24AI144048 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bryan R Greenhouse · 2019 to 2026
$1.6MIllumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600kFACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596kGraduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and governmentT32AI138944 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2018 to 2022
$561kNCATS NIH HHS TL1 TR002647NCI NIH HHS P30 CA054174NIAID NIH HHS F31 AI169993NIAID NIH HHS K24 AI113002NIAID NIH HHS K24 AI144048NIAID NIH HHS R01 AI093615NIAID NIH HHS R01 AI153425NIAID NIH HHS T32 AI138944NIAID NIH HHS U01 AI150741NIAID NIH HHS U19 AI089674NIGMS NIH HHS R35 GM128938NIH HHS S10 OD030311NIH HHS S10 OD030432Wellcome Trust
Abstract
Atypical B cells are a population of activated B cells that are commonly enriched in individuals with chronic immune activation but are also part of a normal immune response to infection or vaccination. To better define the role of atypical B cells in the human adaptive immune response, we performed single-cell sequencing of transcriptomes, cell surface markers, and B cell receptors in individuals with chronic exposure to the malaria parasite
Indexed as
Biological sciencesComponents of the immune systemImmunologyParasitologyTranscriptomics
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What Socratic holds
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.