Evidence map›Paper›PMID 38100614›Full record

ArticleEpigenetics2024

Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth.

Adriana C Vidal, David W Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K Murphy, Sara B Johnson, Billy Schlief, Cathrine Hoyo

Open access · diamondAbstract read
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Adriana C VidalDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
David W SosnowskiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Joddy MarchesoniDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Carole GrenierDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
John ThorpDepartment of Obstetrics and Gynecology, Maternal and Child Health, UNC Gillings School of Public Health, UNC, Chapel Hill, NC, USA.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.
Sara B JohnsonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Billy SchliefJohns Hopkins All Children's Pediatric Biorepository, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Cathrine HoyoDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
North Carolina State University · USDuke Medical Center · USJohns Hopkins University · USJohns Hopkins All Children's Hospital · USUniversity of North Carolina Health Care · US

Funding

Social adversities, epigenetics, and the obesity epidemicR01MD011746 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2017 to 2021
$4.4M
Prenatal stress and diet, and the fetal epigenomeR01MD017696 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Cathrine Hoyo · 2022 to 2026
$3.2M
Novel imprint control regions (ICRs) responsive to environmental exposuresR01ES032462 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2021 to 2025
$3.0M
NIEHS NIH HHS R01 ES032462NIMHD NIH HHS R01 MD011746NIMHD NIH HHS R01 MD017696
6 · The paper itself

Abstract

Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at

Indexed as

Adverse Childhood ExperiencesRNA, Long NoncodingDNA MethylationFemaleGenomic ImprintingHumansInfant, NewbornPregnancyRNA, Long NoncodingACEsimprinted genesmethylationpregnancyrace

Identifiers

PMID38100614
PMCPMC10730185
OpenAlexW4389778028

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.