Evidence map›Paper›PMID 38100650›Full record

ReviewJournal of medical virology2023

BRD4 as a potential target for human papillomaviruses associated cancer.

Abdul Qawee Rani, Srinivasa Reddy Bonam, Jia Zhou, Jenny Li, Haitao Hu, Xuefeng Liu

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of medical virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Abdul Qawee RaniComprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
Srinivasa Reddy BonamDepartment of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA.
Jia ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA.
Jenny LiComprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
Haitao HuDepartment of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, USA.
Xuefeng LiuComprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-9922-9627
The University of Texas Medical Branch at Galveston · USThe Ohio State University · USThe Ohio State University Wexner Medical Center · US

Funding

Modulation of BRD4 to epigenetically suppress HIVR01AI157852 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HU, HAITAO · 2021 to 2025
$3.0M
Developing Functional Human Cell Models to Study Initiation and Progression of Prostate Cancer between AA and EA menR01CA276474 · NCI · OHIO STATE UNIVERSITY · PI Xuefeng Liu · 2023 to 2026
$2.1M
Conditionally Reprogrammed Cell Model for Castration-Resistant Prostate Cancer (CRPC)R01CA222148 · NCI · OHIO STATE UNIVERSITY · PI LIU, XUEFENG · 2019 to 2022
$1.9M
Evaluation of Pre-Analytical Factors of Urine Samples for Urine Cancer Cell Cultures (UCCC) --A Non-Invasive Biomarker – in Monitoring Response and Recurrence of Bladder CancerU01CA278927 · NCI · OHIO STATE UNIVERSITY · PI LIU, XUEFENG · 2023 to 2025
$1.8M
Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer ClinicsR33CA258016 · NCI · OHIO STATE UNIVERSITY · PI LIU, XUEFENG · 2021 to 2023
$1.2M
NCI NIH HHS R01 CA222148NCI NIH HHS R01 CA276474NCI NIH HHS R33 CA258016NCI NIH HHS U01 CA278927NIAID NIH HHS R01 AI157852NIH HHS
6 · The paper itself

Abstract

Around 99% of cervical cancer and 5%-10% of human cancer are associated with human papillomaviruses (HPV). Notably, the life-cycle of HPV begins by low-level infection of the basal cells of the stratified epithelium, where the viral genomes are replicated and passed on to the daughter proliferating basal cells. The production of new viral particles remains restricted to eventually differentiated cells. HPVs support their persistent infectious cycle by hijacking pivotal pathways and cellular processes. Bromodomain-containing protein 4 (BRD4) is one of the essential cellular factors involved in multiple stages of viral transcription and replication. In this review, we demonstrate the role of BRD4 in the multiple stages of HPV infectious cycle. Also, we provide an overview of the intense research about the cellular functions of BRD4, the mechanism of action of bromodomain and extra terminal inhibitors, and how it could lead to the development of antiviral/anticancer therapies.

Indexed as

NeoplasmsPapillomavirus InfectionsBromodomain Containing ProteinsCell Cycle ProteinsHuman Papillomavirus VirusesHumansNuclear ProteinsPapillomaviridaeTranscription FactorsVirus ReplicationBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsNuclear ProteinsTranscription Factorsantiviral agentscell cultures: research and analysis methodshuman immunodeficiency virus: vrus classificationhuman papillomavirus: virus classificationoncogenesis

Identifiers

PMID38100650
PMCPMC11315413
OpenAlexW4389775907

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.