ArticleCell metabolism2024
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Circulating Fibroblast Growth Factor-21 in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.Current obesity reports · 2025Pooled it
- Hepatic ChREBP Drives Cardiac Remodeling via ApoM Non-transcriptional Repression.Circulation research · 2026Article
- Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells.Innovation (Cambridge (Mass.)) · 2026Article
- The diversity of terminal electron acceptors across eukaryotes.Trends in biochemical sciences · 2026Review
- Why is the tumor microenvironment disordered by NADH/NADRedox biology · 2026Review
- GCKR genetic variants and circulating FGF21 identify a metabolic risk signature in metabolic dysfunction-associated steatotic liver disease.BMC gastroenterology · 2026Article
- A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity.Nature metabolism · 2026Article
- PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.CNS neuroscience & therapeutics · 2026Article
- Changes in the brain [NADFrontiers in aging neuroscience · 2026Review
- Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADPFree radical biology & medicine · 2025Review
- Glucokinase activators contribute to gastrointestinal disease risks through metabolic-immune interplay in the gut-liver axis: insights from a multi-omics study.Acta diabetologica · 2025Article
- Reductive stress: The key pathway in metabolic disorders induced by overnutrition.Journal of advanced research · 2025Review
- Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency.Nature metabolism · 2025Article
- Article
- Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.Science advances · 2025Review
- Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism.Cell reports · 2025Article
- Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy.Communications biology · 2025Article
- Reductive stress-a common metabolic feature of obesity and cancer.Acta pharmaceutica Sinica. B · 2024Review
- Type 2 diabetes: a sacrifice program handling energy surplus.Life metabolism · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 1 country.
Charandeep SinghLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Byungchang JinLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Nirajan ShresthaLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Andrew L MarkhardHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Apekshya PandaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Sarah E CalvoHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Amy DeikBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Xingxiu PanThe Scintillon Institute, San Diego, CA 92121, USA.
Austin L ZuckermanThe Scintillon Institute, San Diego, CA 92121, USA; Program in Mathematics and Science Education, University of California, San Diego, La Jolla, CA 92093; Program in Mathematics and Science Education, San Diego State University, San Diego, CA 92120.
Amel Ben SaadDivision of Gastroenterology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Kathleen E CoreyLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Julia SjoquistLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Stephanie OsganianLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Roya AminiTabriziMetabolomics Platform, Comprehensive Cancer Center, the University of Chicago, Chicago, IL 60637, USA.
Eugene P RheeEndocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Hardik ShahMetabolomics Platform, Comprehensive Cancer Center, the University of Chicago, Chicago, IL 60637, USA.
Olga GoldbergerHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Alan C MullenDivision of Gastroenterology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Valentin CracanThe Scintillon Institute, San Diego, CA 92121, USA; Department of Chemistry, the Scripps Research Institute, La Jolla, CA 92037, USA.
Clary B ClishBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Russell P GoodmanLiver Center, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: rpgoodman@mgh.harvard.edu.
Massachusetts General Hospital · USBroad Institute · USHoward Hughes Medical Institute · USUniversity of Chicago · USUniversity of Massachusetts Chan Medical School · USSan Diego State University · USScintillon Institute · USScripps Research Institute · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MMitochondrial Parts, Pathways, and PathogenesisR35GM122455 · NIGMS · BROAD INSTITUTE, INC. · PI MOOTHA, VAMSI KRISHNA · 2017 to 2021
$4.0MExpanding the set of genetically encoded tools for compartment-specific manipulation of redox metabolism in living cellsR35GM142495 · NIGMS · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI Valentin Cracan · 2021 to 2026
$3.2MAn NADH-ChREBP axis in fatty liver disease and dyslipidemiaR01DK134675 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Russell Paul Goodman · 2023 to 2026
$2.0MA METABOLIC BIOMARKER OF HEPATIC NADH/NAD+ RATIOK08DK115881 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GOODMAN, RUSSELL PAUL · 2018 to 2022
$865kIdentifying genetic regulators of hepatic reductive stress in diversity outbred miceR03DK131243 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GOODMAN, RUSSELL PAUL · 2022 to 2023
$260kDefining and targeting the compartmentalization of redox metabolism in aging using novel genetically encoded toolsR03AG067301 · NIA · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI CRACAN, VALENTIN · 2020 to 2021
$192kEngineered flavin-dependent enzymes for probing redox environment and regulationK99GM121856 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI CRACAN, VALENTIN · 2017 to 2018
$180kNIA NIH HHS R03 AG067301NIDDK NIH HHS K08 DK115881NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK134675NIDDK NIH HHS R03 DK131243NIGMS NIH HHS K99 GM121856NIGMS NIH HHS R35 GM122455NIGMS NIH HHS R35 GM142495Wellcome Trust
Abstract
Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide association studies (GWASs), making GCKR one of the most pleiotropic GWAS loci in the genome. It is unclear why. Prior work has demonstrated that GCKR influences the hepatic cytosolic NADH/NAD
Indexed as
Genome-Wide Association StudyGlucokinaseAdaptor Proteins, Signal TransducingBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGlucoseHumansLiverTranscription FactorsAdaptor Proteins, Signal TransducingBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGCKR protein, humanGlucokinaseGlucoseMLXIPL protein, humanTranscription FactorsChREBPfatty liver diseaseFGF21gastric bypass surgeryGCKGCKRmetabolismMLIXPLNAD(+)NADHreductive stresstrigylcerides
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.