Evidence map›Paper›PMID 38106005›Full record

ArticlebioRxiv : the preprint server for biology2023

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion.

Nikaya Polsani, Theodora Yung, Evan Thomas, Melissa Phung-Rojas, Isha Gupta, Julie Denker, Xiaotian Feng, Beatriz Ibarra, Sevan Hopyan, Radhika P Atit

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nikaya PolsaniDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-5343-4759
Theodora YungProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5435-0917
Evan ThomasProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Melissa Phung-RojasDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-4348-2727
Isha GuptaDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Julie DenkerDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Xiaotian FengDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-8736-5536
Beatriz IbarraDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-9744-2811
Sevan HopyanProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-7201-8902
Radhika P AtitDepartment of Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-3492-6552
Hospital for Sick Children · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apical expansion of calvarial osteoblast progenitors from the cranial mesenchyme (CM) above the eye is integral for calvarial growth and enclosure of the brain. The cellular behaviors and signals underlying the morphogenetic process of calvarial expansion are unknown. During apical expansion, we found that mouse calvarial primordia have consistent cellular proliferation, density, and survival with complex tissue scale deformations, raising the possibility that morphogenetic movements underlie expansion. Time lapse light sheet imaging of mouse embryos revealed that calvarial progenitors intercalate in 3D to converge supraorbital arch mesenchyme mediolaterally and extend it apically. In contrast, progenitors located further apically exhibited protrusive and crawling activity. CM cells express non-canonical Wnt/Planar Cell Polarity (PCP) core components and calvarial osteoblasts are bidirectionally polarized. We found non-canonical ligand,

Identifiers

PMID38106005
PMCPMC10723314
OpenAlexW4389393930

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.