Evidence map›Paper›PMID 38106068›Full record

ArticlebioRxiv : the preprint server for biology2023

The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations.

Marcus Harrell, Ziyi Liu, Bethany F Campbell, Olivia Chinsen, Tian Hong, Maitreyi Das

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marcus HarrellBiology Department, Boston College, Chestnut Hill, MA, 02467.
Ziyi LiuDepartment of Biochemistry and Cellular & Molecular Biology, University of Tennessee, TN, 37916.
Bethany F CampbellBiology Department, Boston College, Chestnut Hill, MA, 02467.
Olivia ChinsenBiology Department, Boston College, Chestnut Hill, MA, 02467.
Tian HongDepartment of Biochemistry and Cellular & Molecular Biology, University of Tennessee, TN, 37916.
Maitreyi DasBiology Department, Boston College, Chestnut Hill, MA, 02467.ORCID 0000-0001-9164-0158
Boston College · USUniversity of Tennessee at Knoxville · US

Funding

Cell-cycle-dependent cell polarity controlR01GM136847 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI DAS, MAITREYI · 2020 to 2024
$1.5M
Modeling transcriptional and post-transcriptional systems for regulating non-genetic heterogeneity in mammalian cellsR35GM149531 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Tian Hong · 2023 to 2026
$1.5M
NIGMS NIH HHS R01 GM136847NIGMS NIH HHS R35 GM149531
6 · The paper itself

Abstract

The conserved GTPase Cdc42 is a major regulator of polarized growth in most eukaryotes. Cdc42 periodically cycles between active and inactive states at sites of polarized growth. These periodic cycles are caused by positive feedback and time-delayed negative feedback loops. In the bipolar yeast

Indexed as

Arp2/3 complexCdc42endocytosisMyo1OscillationsPak1 kinase

Identifiers

PMID38106068
PMCPMC10723479
OpenAlexW4388671471

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.