ArticlemedRxiv : the preprint server for health sciences2023
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Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
33 authors.
Nijole P TjaderDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0000-0001-7438-9942
Abigail J BeerDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0000-0003-3927-9451
Johnny RamroopThe City College of New York, City University of New York, New York, NY, USA.ORCID 0000-0003-1574-2106
Mei-Chee TaiCancer Research Malaysia, Subang Jaya, Selangor 47500, Malaysia.ORCID 0000-0002-6191-9593
Jie PingDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203.ORCID 0000-0001-9907-5819
Tanish GandhiBiomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0007-6479-2173
Cara DauchDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0003-4783-9209
Susan L NeuhausenBeckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.ORCID 0000-0001-5053-0390
Elad ZivUniversity of California, Helen Diller Family Comprehensive Cancer Center, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2324-2884
Nereida SoteloDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0007-7174-4575
Shreya GhanekarDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0001-7653-6990
Owen MeadowsBiomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0005-6833-2823
Monica ParedesBiomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0009-0000-9343-6767
Jessica GillespieThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.ORCID 0009-0002-1592-193X
Amber AeiltsDepartment of Internal Medicine, Division of Human Genetics, The Ohio State University, Columbus, OH, 43210, USA.ORCID 0000-0001-8907-7853
Heather HampelDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0001-7558-9794
Wei ZhengDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203.ORCID 0000-0003-1226-070X
Guochong JiaDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN 37203.ORCID 0000-0002-8455-1832
Qiang HuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-4090-5539
Lei WeiDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-1881-8666
Song LiuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-6351-2941
Christine B AmbrosoneDepartment of Cancer Control and Prevention, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0003-1717-9943
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.ORCID 0000-0002-6534-335X
John D CarptenCity of Hope Comprehensive Cancer Center, Duarte, CA, USA.ORCID 0000-0002-6862-2821
Song YaoDepartment of Cancer Control and Prevention, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-9442-1313
Patrick StevensThe Ohio State University Comprehensive Cancer Center, Bioinformatics Shared Resource, Columbus, OH, USA.ORCID 0000-0002-5288-195X
Weang-Kee HoCancer Research Malaysia, Subang Jaya, Selangor 47500, Malaysia.ORCID 0000-0002-8269-7344
Jia Wern PanCancer Research Malaysia, Subang Jaya, Selangor 47500, Malaysia.ORCID 0000-0003-0875-9831
Paolo FaddaThe Ohio State University Comprehensive Cancer Center, Genomics Shared Resource, Columbus, OH, USA.ORCID 0000-0001-9444-1461
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, 60637, USA.ORCID 0000-0002-4041-1678
Soo-Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor 47500, Malaysia.ORCID 0000-0002-0444-590X
Joseph Paul McElroyThe Ohio State University Center for Biostatistics, Department of Biomedical Informatics, Columbus, OH, USA.ORCID 0000-0003-0366-1210
Amanda Ewart TolandDepartment of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0000-0002-0271-1792
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3MTransgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3MBreast Cancer genetic study in African-ancestry populationsR01CA202981 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wei Zheng · 2016 to 2026
$14.1MImmuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCIU24CA232979 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HUTSON, ALAN DAVID, LIU, SONG · 2018 to 2024
$8.9MYAP1 and RB1 cooperate to regulate lung cancer lineage plasticity and therapeutic resistanceU24CA274159 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI DAVID W. GOODRICH, Alan David Hutson · 2022 to 2026
$8.5MSomatic Mutations and Their Etiological Determinants for Breast Cancer in African American WomenR01CA228156 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CARPTEN, JOHN D., PALMER, JULIE R · 2019 to 2023
$6.5MGermline and Tumor Genomic Analyses of Breast Cancer in LatinasR01CA184585 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NEUHAUSEN, SUSAN L., ZIV, ELAD · 2014 to 2018
$4.2MPolygenic Risk Prediction of Breast Cancer for Women of African DescentR01CA228198 · NCI · UNIVERSITY OF CHICAGO · PI Dezheng Huo · 2018 to 2026
$3.9MAdvancing skin cancer prevention by tackling UV-induced clonogenic mutationsR01CA255242 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI PARAGH, GYORGY, WEI, LEI · 2021 to 2025
$3.2MEtiology and Genomics of Breast Cancer Progression in Women of African AncestryR01MD013452 · NIMHD · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2019 to 2023
$2.8MGenetics of mammographic density and breast cancer risk in LatinasK24CA169004 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2012 to 2021
$1.8MNCI NIH HHS K24 CA169004NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA033572NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA184585NCI NIH HHS R01 CA202981NCI NIH HHS R01 CA215151NCI NIH HHS R01 CA228156NCI NIH HHS R01 CA228198NCI NIH HHS R01 CA255242NCI NIH HHS U24 CA232979NCI NIH HHS U24 CA274159NIMHD NIH HHS R01 MD013452Wellcome Trust
Abstract
Background: In breast tumors, somatic mutation frequencies in Methods: A genome-wide association study was conducted using breast cancer mutation status of Results: The discovery Germline x Mutation (GxM) association study found five variants associated with one or more Conclusions: We found evidence that germline variants were associated with
Indexed as
breast cancerESR1germlinegermline by somatic interactionGWASPIK3CAsomaticTP53
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.