Evidence map›Paper›PMID 38106145›Full record

ArticlebioRxiv : the preprint server for biology2023

Cooperative Gsx2-DNA Binding Requires DNA Bending and a Novel Gsx2 Homeodomain Interface.

Jordan A Webb, Edward Farrow, Brittany Cain, Zhenyu Yuan, Alexander E Yarawsky, Emma Schoch, Ellen K Gagliani, Andrew B Herr, Brian Gebelein, Rhett A Kovall

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jordan A WebbDepartment of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-1372-7578
Edward FarrowGraduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.
Brittany CainDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA.
Zhenyu YuanDepartment of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0002-2295-4505
Alexander E YarawskyDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, 3333, Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0002-5973-5058
Emma SchochDepartment of Medical Education, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0003-2058-7366
Ellen K GaglianiDepartment of Chemistry, Xavier University, Cincinnati, OH 45207, USA.ORCID 0000-0001-7270-6254
Andrew B HerrDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, 3333, Burnet Ave, Cincinnati, OH 45229, USA.ORCID 0000-0002-3598-3399
Brian GebeleinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, USA.ORCID 0000-0001-9791-9061
Rhett A KovallDepartment of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-0520-1613
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati Medical Center · USXavier University · US

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
Mechanisms of Homeodomain Transcriptional SpecificityR01GM079428 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI GEBELEIN, BRIAN · 2008 to 2023
$4.5M
Roles of Gsx factors in basal ganglia developmentR01NS124660 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI KENNETH J CAMPBELL, BRIAN GEBELEIN · 2022 to 2026
$3.0M
NIEHS NIH HHS T32 ES007250NIGMS NIH HHS R01 GM079428NINDS NIH HHS R01 NS124660
6 · The paper itself

Abstract

The conserved Gsx homeodomain (HD) transcription factors specify neural cell fates in animals from flies to mammals. Like many HD proteins, Gsx factors bind A/T-rich DNA sequences prompting the question - how do HD factors that bind similar DNA sequences

Indexed as

cooperativeGsxHomeodomaintranscription factor

Identifiers

PMID38106145
PMCPMC10723402
OpenAlexW4389498194

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.