Evidence map›Paper›PMID 38110410›Full record

ArticleNature communications2023

Recently activated CD4 T cells in tuberculosis express OX40 as a target for host-directed immunotherapy.

Abigail R Gress, Christine E Ronayne, Joshua M Thiede, David K Meyerholz, Samuel Okurut, Julia Stumpf, Tailor V Mathes, Kenneth Ssebambulidde, David B Meya, Fiona V Cresswell and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. A CD40-OX40 co-stimulatory circuit orchestrates protective CD4Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Abigail R GressDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.
Christine E RonayneDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.
Joshua M ThiedeDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.ORCID 0000-0002-6603-281X
David K MeyerholzDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicine, 1165 Medical Laboratories (ML), 51 Newton Rd, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0003-1552-3253
Samuel OkurutInfectious Diseases Institute, P.O. Box 22418, Makerere University, Kampala, Uganda.ORCID 0000-0002-9292-8687
Julia StumpfDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.
Tailor V MathesDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.ORCID 0000-0002-3179-1672
Kenneth SsebambuliddeInfectious Diseases Institute, P.O. Box 22418, Makerere University, Kampala, Uganda.ORCID 0000-0002-8125-0698
David B MeyaInfectious Diseases Institute, P.O. Box 22418, Makerere University, Kampala, Uganda.
Fiona V CresswellInfectious Diseases Institute, P.O. Box 22418, Makerere University, Kampala, Uganda.ORCID 0000-0002-5070-532X
David R BoulwareDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA.ORCID 0000-0002-4715-0060
Tyler D BoldDepartment of Medicine, University of Minnesota, 420 Delaware Street, SE MMC 250, Minneapolis, MN, 55455, USA. tbold@umn.edu.ORCID 0000-0001-7360-6546
University of Minnesota · USInfectious Diseases Institute · UGBrighton and Sussex Medical School · GBUniversity of Iowa · US

Funding

TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
IMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7M
TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory TherapiesR01AI162786 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R, MEYA, DAVID BISAGAYA · 2021 to 2025
$3.3M
Harnessing activated CD4 T cells to define new mechanisms of protection in tuberculosisR01AI173780 · NIAID · UNIVERSITY OF MINNESOTA · PI Tyler Dallas Bold · 2023 to 2026
$2.4M
Determinants of antigen specific CD4 T cell function in tuberculosisK08AI150425 · NIAID · UNIVERSITY OF MINNESOTA · PI BOLD, TYLER DALLAS · 2021 to 2025
$1.0M
Medical Research Council MR/S004963/1NHLBI NIH HHS T32 HL007741NIAID NIH HHS K08 AI150425NIAID NIH HHS L30 AI140336NIAID NIH HHS R01 AI162786NIAID NIH HHS R01 AI173780NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI055433
6 · The paper itself

Abstract

After Mycobacterium tuberculosis (Mtb) infection, many effector T cells traffic to the lungs, but few become activated. Here we use an antigen receptor reporter mouse (Nur77-GFP) to identify recently activated CD4 T cells in the lungs. These Nur77-GFP

Indexed as

CD4-Positive T-LymphocytesTuberculosisAnimalsCD8-Positive T-LymphocytesHumansImmunotherapyMiceReceptors, OX40Receptors, OX40

Identifiers

PMID38110410
PMCPMC10728168
OpenAlexW4389941562

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.