Evidence map›Paper›PMID 38112458›Full record

ArticleJournal of applied biomedicine2023

Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion.

Hongji Wang, Lisha Chen, Juping Xing, Xiangchao Shi, Changshui Xu

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Journal of applied biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hongji WangBasic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Lisha ChenBasic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Juping XingBasic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Xiangchao ShiBasic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Changshui XuBasic Medical College of Nanchang University, Department of Physiology, Nanchang, 330006, P.R. China.
Nanchang University · CN

Funding

Jiangxi Province Human Resources and Social Security Department) 2022233Jiangxi Provincial Natural Science Foundation 20202BAB206027Jiangxi Provincial Natural Science Foundation 20232ACB206020
6 · The paper itself

Abstract

Naringin inhibits inflammation and oxidative stress, the P2 purinoreceptor X4 receptor (P2X4R) is associated with glial cell activation and inflammation, the purpose of this study is to investigate the effects of naringin on P2X4 receptor expression on satellite glial cells (SGCs) and its possible mechanisms. ATP promoted the SGC activation and upregulated P2X4R expression; naringin inhibited SGC activation, decreased expression of P2X4R, P38 MAPK/ERK, and NF-κB, and reduced levels of Ca2+, TNF-α, and IL-1β in SGCs in an ATP-containing environment. These findings suggest that naringin attenuates the ATP-induced SGC activation and reduces P2X4R expression via the Ca2+-P38 MAPK/ERK-NF-κB pathway.

Indexed as

NF-kappa BReceptors, Purinergic P2X4Adenosine TriphosphateAnimalsAnimals, NewbornCalciumFlavanonesGanglia, SpinalInflammationNeurogliap38 Mitogen-Activated Protein KinasesRatsRats, Sprague-DawleyAdenosine TriphosphateCalciumFlavanonesnaringinNF-kappa Bp38 Mitogen-Activated Protein KinasesReceptors, Purinergic P2X4Glial cell activationInflammationNaringinP2X4RSatellite glial cells

Identifiers

PMID38112458
OpenAlexW4389307969

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.