Evidence map›Paper›PMID 38115115›Full record

ArticleVirology journal2023

Transcriptomic analysis reveals impact of gE/gI/TK deletions on host response to PRV infection.

Xiaoli Wang, Yingguang Li, Shaoming Dong, Cong Wang, Yongming Wang, Hongliang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiaoli Wang *Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian, China.
Yingguang Li *Shandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Shaoming DongShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Cong WangChina animal husbandry industry Co., Ltd, Beijing, China.
Yongming WangShandong Huahong Biological Engineering Co., Ltd, Binzhou, China.
Hongliang ZhangShandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China. zhanghongliang001@126.com.
Qingdao Agricultural University · CNNational Animal Husbandry Service · CNShandong Agricultural University · CN

Funding

Hongliang Zhang This research was funded by the Pig Industry Technology System of Shandong Province (Number: SDAIT-08-07) and the Shandong Key Research and Development Program, China Number: 2019GNC106074 and 2017GRC5201).
6 · The paper itself

Abstract

backgroundPseudorabies virus (PRV) causes substantial losses in the swine industry worldwide. Attenuated PRV strains with deletions of immunomodulatory genes glycoprotein E (gE), glycoprotein I (gI) and thymidine kinase (TK) are candidate vaccines. However, the effects of gE/gI/TK deletions on PRV-host interactions are not well understood.

methodsTo characterize the impact of gE/gI/TK deletions on host cells, we analyzed and compared the transcriptomes of PK15 cells infected with wild-type PRV (SD2017), PRV with gE/gI/TK deletions (SD2017gE/gI/TK) using RNA-sequencing.

resultsThe attenuated SD2017gE/gI/TK strain showed increased expression of inflammatory cytokines and pathways related to immunity compared to wild-type PRV. Cell cycle regulation and metabolic pathways were also perturbed.

conclusionsDeletion of immunomodulatory genes altered PRV interactions with host cells and immune responses. This study provides insights into PRV vaccine design.

Indexed as

Herpesvirus 1, SuidPseudorabiesSwine DiseasesAnimalsGene Expression ProfilingGlycoproteinsSwineThymidine KinaseViral Envelope ProteinsGlycoproteinsThymidine KinaseViral Envelope ProteinsgE/gI/TKGene deletionsMutantPK15 cellsPseudorabies virusTranscriptome

Identifiers

PMID38115115
PMCPMC10731697
OpenAlexW4389949447

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.