Hepatoprotective effect of hydromethanol extract of

Endalkachew Gugsa, Tewodros Shibabaw Molla, Tesfahun Bekele, Tadesse Asmamaw Dejenie

Open access · goldAbstract read

In one paragraph

Article in Metabolism open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.0field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Exploring the Anti-Inflammatory Potential ofAdvances in pharmacological and pharmaceutical sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Endalkachew GugsaDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Tewodros Shibabaw MollaDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Tesfahun BekeleDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Tadesse Asmamaw DejenieDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

University of Gondar · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Drug-induced liver injury is the most common cause of acute liver failure. Off-Target effect "hepatotoxicity "frequently detected during clinical examination of patients on Methods: Results: Group II mice's serum ALT, AST and total bilirubin levels were significantly increased and serum total protein and albumin levels were significantly decreased as compared with group I mice. The groups of mice treated with Conclusion: Evidence from our study revealed that the hydromethanol extract of O. integrifolia has a hepatoprotective effect against isoniazid and rifampicin-induced hepatotoxicity in Swiss Albino mice. This protective effect of O. integrifolia extract may be based on its metal ion reducing power, free radical scavenging activity, and anti-inflammatory activity and could be used as a potential therapeutic option.

Indexed as

HepatotoxicityIsoniazidOtostegia integrifoliaOxidative stressRifampicin

Identifiers

PMID38115863

DOI10.1016/j.metop.2023.100255

PMCPMC10728564

OpenAlexW4387826899

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.