Evidence map›Paper›PMID 38117594›Full record

ArticleMolecular biology of the cell2024

Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells.

Chase Amos, Volker Kiessling, Alex J B Kreutzberger, Noah A Schenk, Ramkumar Mohan, Sarah Nyenhuis, Catherine A Doyle, Hong-Yin Wang, Kandice Levental, Ilya Levental and 2 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Chase AmosDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Volker KiesslingDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Alex J B KreutzbergerDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Noah A SchenkDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Ramkumar MohanDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Sarah NyenhuisDepartment of Chemistry, University of Virginia, Charlottesville, VA, 22904.
Catherine A DoyleDepartment of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908.
Hong-Yin WangDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Kandice LeventalDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Ilya LeventalDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
Arun AnantharamDepartment of Neurosciences, University of Toledo, Toledo, OH 43614.
Lukas K TammDepartment of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, VA 22908.
University of Virginia Health System · USUniversity of Toledo · USUniversity of Virginia · US

Funding

Structural Dynamics of the Exocytotic Fusion Machine in Neurons.P01GM072694 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KIESSLING, VOLKER · 2005 to 2021
$17.4M
Pre- and postsynaptic pathways underlying the stress response in the adrenal medullaR01NS122534 · NINDS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI ANANTHARAM, ARUN · 2021 to 2025
$1.8M
Development of a high resolution assay to characterize exocytotic vesicle fusion.R21NS118319 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LINDAU, MANFRED · 2020 to 2020
$461k
NIGMS NIH HHS P01 GM072694NINDS NIH HHS R01 NS122534NINDS NIH HHS R21 NS118319
6 · The paper itself

Abstract

Insulin secretion depends on the Ca

Indexed as

Insulin-Secreting CellsMembrane FusionCalciumCell MembraneExocytosisMembrane LipidsRecombinant ProteinsSNARE ProteinsSynaptotagmin ICalciumMembrane LipidsRecombinant ProteinsSNARE ProteinsSynaptotagmin I

Identifiers

PMID38117594
PMCPMC10916878
OpenAlexW4389991539

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.