Evidence map›Paper›PMID 38123565›Full record

ArticleNature communications2023

Adult stem cell activity in naked mole rats for long-term tissue maintenance.

Shamir Montazid, Sheila Bandyopadhyay, Daniel W Hart, Nan Gao, Brian Johnson, Sri G Thrumurthy, Dustin J Penn, Bettina Wernisch, Mukesh Bansal, Philipp M Altrock and 13 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 6 countries.

Shamir Montazid *Nuffield Department of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.ORCID 0000-0002-4584-5619
Sheila Bandyopadhyay *Department of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.
Daniel W HartMammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0028, Republic of South Africa.
Nan GaoDepartment of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.
Brian JohnsonDivision of Biomedical Informatics, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, 92093, CA, USA.ORCID 0000-0002-9477-4677
Sri G ThrumurthyEndoscopy, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.
Dustin J PennKonrad Lorenz Institute of Ethology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, 1160, Austria.
Bettina WernischKonrad Lorenz Institute of Ethology, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine, Vienna, 1160, Austria.
Mukesh BansalBristol Myers Squibb, San Diego, 92121, CA, USA.
Philipp M AltrockDepartment for Theoretical Biology, Max Planck Institute for Evolutionary Biology, 24306, Ploen, Germany.ORCID 0000-0001-7731-3345
Fabian RostDRESDEN-concept Genome Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, 01307, Dresden, Germany.ORCID 0000-0001-6466-2589
Patrycja GazinskaBiobank Research Group, Lukasiewicz Research Network, PORT Polish Center for Technology Development, Wroclaw, Poland.
Piotr ZiolkowskiDepartment of Clinical and Experimental Pathology, Wroclaw Medical University, 50-368, Wroclaw, Poland.
Bu'Hussain HayeeEndoscopy, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.
Yue LiuDepartment of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.
Jiangmeng HanDepartment of Biological Sciences, Rutgers University, Newark, 07102, NJ, USA.
Annamaria TessitoreNovo Nordisk Research Centre Oxford, Oxford, OX37FZ, UK.
Jana KothWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.ORCID 0000-0002-6388-9308
Walter F BodmerWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.
James E EastTranslational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.ORCID 0000-0001-8035-3700
Nigel C BennettMammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0028, Republic of South Africa.
Ian TomlinsonDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, UK. ian.tomlinson@oncology.ox.ac.uk.ORCID 0000-0003-3037-1470
Shazia IrshadNuffield Department of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. shazia.irshad@ndcls.ox.ac.uk.ORCID 0000-0003-4536-373X
Rutgers, The State University of New Jersey · USUniversity of Oxford · GBJohn Radcliffe Hospital · GBKing's College Hospital NHS Foundation Trust · GBUniversity of Pretoria · ZAUniversity of Veterinary Medicine Vienna · ATBristol-Myers Squibb (United States) · USCenter for Systems Biology Dresden · DEŁukasiewicz Research Network – PORT Polish Center for Technology Development · PLMax Planck Institute for Evolutionary Biology · DENovo Nordisk (United Kingdom) · GBUniversity of California San Diego · USWroclaw Medical University · PL

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
Paneth cell heterogeneity in infection and inflammationR01DK132885 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Nan Gao · 2022 to 2026
$2.4M
Research Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9M
Cancer Research UK C6199/A27327NIDDK NIH HHS R01 DK119198NIDDK NIH HHS R01 DK132885NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5

Indexed as

Adult Stem CellsLongevityAnimalsHumansIntestinal MucosaIntestinesMiceMole RatsReceptors, G-Protein-CoupledReceptors, G-Protein-Coupled

Identifiers

PMID38123565
PMCPMC10733326
OpenAlexW4389991401

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.