Evidence map›Paper›PMID 38126089›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Carotid body denervation improves hyperglycemia in obese mice.

Mi-Kyung Shin, Wan-Yee Tang, Mateus R Amorim, James S-K Sham, Vsevolod Y Polotsky

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mi-Kyung ShinDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States.ORCID 0000-0003-0755-157X
Wan-Yee TangDepartment of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States.
Mateus R AmorimDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States.
James S-K ShamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-3571-8712
Vsevolod Y PolotskyDepartment of Anesthesiology and Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States.ORCID 0000-0002-2951-7535
George Washington University · USJohns Hopkins University · USUniversity of Pittsburgh · US

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
American Heart Association (AHA) 19CDA34700025HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL133100NHLBI NIH HHS R01 HL133100
6 · The paper itself

Abstract

The carotid bodies (CBs) have been implicated in glucose abnormalities in obesity via elevation of activity of the sympathetic nervous system. Obesity-induced hypertension is mediated by insulin receptor (INSR) signaling and by leptin, which binds to the leptin receptor (LEPR

Indexed as

Carotid BodyHyperglycemiaHypertensionInsulin ResistanceInsulinsTRPM Cation ChannelsAnimalsBlood GlucoseDenervationGlucoseLeptinLiver GlycogenMaleMiceMice, ObeseObesityBlood GlucoseGlucoseInsulinsLeptinLiver GlycogenTrpm7 protein, mouseTRPM Cation Channelscarotid bodyglucose metabolismleptinobeseTrpm7

Identifiers

PMID38126089
PMCPMC11219014
OpenAlexW4390053524

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.