Evidence map›Paper›PMID 38130770›Full record

ArticleJBMR plus2023

Nicholas J Chargo, Jonathan D Schepper, Naoimy Rios-Arce, Ho Jun Kang, Joseph D Gardinier, Narayanan Parameswaran, Laura R McCabe

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Cross-talks between osteoporosis and gut microbiome.World journal of orthopedics · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicholas J ChargoDepartment of Physiology Michigan State University East Lansing MI USA.ORCID https://orcid.org/0000-0001-5537-3080
Jonathan D SchepperDepartment of Physiology Michigan State University East Lansing MI USA.ORCID https://orcid.org/0000-0003-1888-0950
Naoimy Rios-ArceDepartment of Physiology Michigan State University East Lansing MI USA.
Ho Jun KangDepartment of Physiology Michigan State University East Lansing MI USA.
Joseph D GardinierBone and Joint Center Henry Ford Health System Detroit MI USA.ORCID https://orcid.org/0000-0002-8651-8913
Narayanan ParameswaranDepartment of Physiology Michigan State University East Lansing MI USA.
Laura R McCabeDepartment of Physiology Michigan State University East Lansing MI USA.ORCID https://orcid.org/0000-0001-5407-162X
Michigan State University · USHenry Ford Health System · US

Funding

Mechanistic basis of probiotic prevention of osteoporosisR01AT007695 · NCCIH · MICHIGAN STATE UNIVERSITY · PI BRITTON, ROBERT A, MCCABE, LAURA R · 2013 to 2017
$2.2M
NCCIH NIH HHS R01 AT007695
6 · The paper itself

Abstract

Glucocorticoids (GCs) are commonly used anti-inflammatory medications with significant side effects, including glucocorticoid-induced osteoporosis (GIO). We have previously demonstrated that chronic subcutaneous GC treatment in mice leads to gut barrier dysfunction and trabecular bone loss. We further showed that treating with probiotics or barrier enhancers improves gut barrier function and prevents GIO. The overall goal of this study was to test if probiotics could prevent GC-induced gut barrier dysfunction and bone loss in a clinically relevant oral-GC model of GIO. Eight-week-old male CD-1 mice were treated with vehicle or corticosterone in the drinking water for 4 weeks and administered probiotics

Indexed as

BARRIERGLUCOCORTICOIDGUT‐BONE INTERACTIONSOSTEOPOROSISPROBIOTIC

Identifiers

PMID38130770
PMCPMC10731127
OpenAlexW4385792110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.