ArticleScience advances2023
A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Efficacy and safety of esketamine for sedation during colonoscopy: A systematic review and Meta-analysis of randomized controlled trials.European journal of clinical pharmacology · 2026Pooled it
- Efficacy and safety of esketamine combined with propofol for conscious sedation in painless colonoscopy: a prospective, randomized, double-blind controlled clinical trial.BMC anesthesiology · 2024Trial
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
- Hepatotoxic mechanisms of functionalized nanopolystyrene: decoding the role of ionic surface groups.Hepatology international · 2026Article
- A Holistic and Dynamic Network-Level View of the Autonomic Nervous System.Annual review of biomedical engineering · 2026Review
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The threat of an embodied virtual belly affects gastric feelings depending on somatic, interoceptive and alexithymic characteristics of healthy women.Scientific reports · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Implantable bioelectronics and wearable sensors for kidney health and disease.Nature reviews. Nephrology · 2025Review
- Volume addiction: introducing a novel phenotype within compulsive high volume eating.Frontiers in public health · 2025Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension. We designed the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill, an ingestible device that performs luminal vibratory stimulation to activate mechanoreceptors and stroke mucosal receptors, which induces serotonin release and yields a hormonal metabolic response commensurate with a fed state. We evaluated VIBES across 108 meals in swine which consistently led to diminished food intake (~40%,
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.