Evidence map›Paper›PMID 38136563›Full record

ArticleBiomolecules2023

The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses.

Abhishek P Shrestha, Megan Stiles, Richard C Grambergs, Johane M Boff, Saivikram Madireddy, Koushik Mondal, Rhea Rajmanna, Hunter Porter, David M Sherry, Richard L Proia and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Abhishek P ShresthaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Megan StilesDepartments of Cell Biology, Neurosurgery, and Pharmacological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Richard C GrambergsDepartment of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Johane M BoffDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0009-9952-0674
Saivikram MadireddyCollege of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Koushik MondalDepartment of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-6557-4273
Rhea RajmannaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Hunter PorterDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
David M SherryDepartments of Cell Biology, Neurosurgery, and Pharmacological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Richard L ProiaGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Thirumalini VaithianathanDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7686-5284
Nawajes MandalDepartment of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-4489-7748
University of Tennessee Health Science Center · USUniversity of Oklahoma Health Sciences Center · USNational Institutes of Health · US

Funding

Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.R01EY030863 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI VAITHIANATHAN, THIRUMALINI · 2021 to 2025
$2.3M
Sphingolipids and their Impact in Corneal Wound HealingR01EY031316 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KARAMICHOS, DIMITRIOS, MANDAL, NAWAJES · 2020 to 2023
$1.8M
Sphingolipid Metabolism and Signaling in the RetinaR01EY022071 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MANDAL, NAWAJES · 2012 to 2016
$1.8M
BLRD VA I01 BX004893NEI NIH HHS R01 EY022071NEI NIH HHS R01 EY030863NEI NIH HHS R01EY030863 ; EY022071, R01 EY031316NEI NIH HHS R01 EY031316
6 · The paper itself

Abstract

The bioactive sphingolipid sphingosine-1-phosphate (S1P) acts as a ligand for a family of G protein-coupled S1P receptors (S1PR1-5) to participate in a variety of signaling pathways. However, their specific roles in the neural retina remain unclear. We previously showed that S1P receptor subtype 2 (S1PR2) is expressed in murine retinas, primarily in photoreceptors and bipolar cells, and its expression is altered by retinal stress. This study aims to elucidate the role of S1PR2 in the mouse retina. We examined light responses by electroretinography (ERG), structural differences by optical coherence tomography (OCT), and protein levels by immunohistochemistry (IHC) in wild-type (WT) and S1PR2 knockout (KO) mice at various ages between 3 and 6 months. We found that a- and b-wave responses significantly increased at flash intensities between 400~2000 and 4~2000 cd.s/m

Indexed as

ElectroretinographyRetinaAnimalsMiceMice, KnockoutSignal TransductionSphingosine-1-Phosphate ReceptorsSphingosine-1-Phosphate Receptorselectroretinographylight responseretinaretinal synapsessphingolipidsynaptic proteins

Identifiers

PMID38136563
PMCPMC10741782
OpenAlexW4388942167

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.