ReviewBiomolecules2023
Oxidative Stress in Pregnancy.
Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07489664 (Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat), which is not on this map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- The impact of scaling and root planning combined with mouthwash during pregnancy on preterm birth and low birth weight: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Women with moderate anaemia prior to conception benefited most from nutrition interventions: a secondary analysis of the Women First preconception maternal nutrition trial.BMJ global health · 2026Trial
- Effects of Adding Transversus Abdominis Plane Block on Intravenous Nalbuphine and Dexmedetomidine for Severely Pre-Eclamptic Parturients After Cesarean Delivery.The Kaohsiung journal of medical sciences · 2025Trial
- The role of miRNA in modulating oxidative stress in preeclampsia: current knowledge.RNA biology · 2026Review
- Article
- Selected Trace Elements in Blood of Women with Preeclampsia in Kongo Central, DR Congo.Biological trace element research · 2026Article
- Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes-A Prospective Cohort Study.Antioxidants (Basel, Switzerland) · 2026Article
- Maternal biological ageing and telomere attrition across parity, pregnancy, and the postpartum period.Biogerontology · 2026Review
- Maternal oxidative stress biomarkers across pregnancy in relation to fetal growth: evidence from the TIDES cohort.American journal of epidemiology · 2026Article
- Biomarkers of Maternal and Neonatal Oxidative and Nitrosative Stress During Delivery: An Exploratory Pilot Study on Maternal-Neonatal Adaptation to Stress.Journal of clinical medicine · 2026Article
- Racialized Economic Segregation and Disparities in the Risk of Stillbirth.Journal of racial and ethnic health disparities · 2026Article
- Gestational stage-related changes in hepatic Nrf1 and Nrf2 immunoreactivity in mid to late rat pregnancy.Histochemistry and cell biology · 2026Article
- [Interaction between oxidative stress and inflammatory processes in fetal membranes: One Health].Revista medica del Instituto Mexicano del Seguro Social · 2026Review
- Association of treatment for prenatal depression with cardiovascular disease within 24 months after delivery.Pregnancy (Hoboken, N.J.) · 2026Article
- Longitudinal Assessment of Oxidative Stress Biomarkers During Physiological Pregnancy and Their Relevance for Maternal Healthcare.Healthcare (Basel, Switzerland) · 2026Article
- Life-Course Programming of Kidney Disease: Roles of Gut Microbiota Dysbiosis and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- Antenatal N-acetylcysteine supplementation in pregnant women with impending preterm birth: a prospective randomized placebo-controlled trial.Pediatric research · 2026Article
- Advanced nanoformulations of NUAK1 regulate NLRP3 inflammasome for preeclampsia management in mice.Nature communications · 2026Article
- Lower oxidative balance score is linked to increased miscarriage risk: findings from a case-control study.BMC pregnancy and childbirth · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent years have seen an increased interest in the role of oxidative stress (OS) in pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a systemic inflammatory response that culminates in an elevated presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the circulatory system. The amplified OS in pregnancy can trigger a series of detrimental outcomes such as underdevelopment, abnormal placental function, and a host of pregnancy complications, including pre-eclampsia, embryonic resorption, recurrent pregnancy loss, fetal developmental anomalies, intrauterine growth restriction, and, in extreme instances, fetal death. The body's response to mitigate the uncontrolled increase in RNS/ROS levels requires trace elements that take part in non-enzymatic and enzymatic defense processes, namely, copper (Cu), zinc (Zn), manganese (Mn), and selenium (Se). Determination of ROS concentrations poses a challenge due to their short half-lives, prompting the use of marker proteins, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), and glutathione (GSH). These markers, indicative of oxidative stress intensity, can offer indirect assessments of pregnancy complications. Given the limitations of conducting experimental studies on pregnant women, animal models serve as valuable substitutes for in-depth research. This review of such models delves into the mechanism of OS in pregnancy and underscores the pivotal role of OS markers in their evaluation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.