Evidence map›Paper›PMID 38137355›Full record

ArticleBiomedicines2023

Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance.

Xinguo Zhuang, Tracey A Martin, Fiona Ruge, Jianyuan Jimmy Zeng, Xinyu Amber Li, Elyas Khan, Qingping Dou, Eleri Davies, Wen G Jiang

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Xinguo ZhuangSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Tracey A MartinSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Fiona RugeSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Jianyuan Jimmy ZengSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.ORCID 0000-0001-5759-9710
Xinyu Amber LiSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Elyas KhanKarmanos Cancer Institute, Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Qingping DouSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.ORCID 0000-0002-6465-1473
Eleri DaviesWales Breast Centre, University Llandough Hospital, Cardiff and Vales University Health Board, Cardiff CF64 2XX, UK.
Wen G JiangSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.ORCID 0000-0002-3283-1111
Cardiff University · GBWayne State University · USCardiff and Vale University Health Board · GBFirst Affiliated Hospital of Xiamen University · CN

Funding

National Natural Science Foundation of China (No. 81871305).the Cardiff University-Xiamen University Strategic Partnership Fund 2022ZXG
6 · The paper itself

Abstract

(1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types. The present study investigated the role that CLDN9, along with the subcoat proteins, Zonula Occludens (ZOs), plays in clinical breast cancer and subsequent impact on drug response of patients. (2) Methods: CLDN9 protein and

Indexed as

breast cancerchemoresistancechemotherapiesclaudinCLDN9cytotoxicityestrogen receptorHer-2neratinibprognosisZO-1ZO-3

Identifiers

PMID38137355
PMCPMC10740911
OpenAlexW4388971572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.