Evidence map›Paper›PMID 38137490›Full record

ArticleBiomedicines2023

Association of Endotoxemia with Low-Grade Inflammation, Metabolic Syndrome and Distinct Response to Lipopolysaccharide in Type 1 Diabetes.

Aleksejs Fedulovs, Leonora Pahirko, Kaspars Jekabsons, Liga Kunrade, Jānis Valeinis, Una Riekstina, Valdis Pīrāgs, Jelizaveta Sokolovska

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Dextran sulfate restores endotoxin detectability in human serum.Analytical and bioanalytical chemistry · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aleksejs FedulovsFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0002-5920-3772
Leonora PahirkoFaculty of Physics, Mathematics and Optometry, University of Latvia, LV-1004 Riga, Latvia.
Kaspars JekabsonsFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0003-3127-6694
Liga KunradeFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.
Jānis ValeinisFaculty of Physics, Mathematics and Optometry, University of Latvia, LV-1004 Riga, Latvia.
Una RiekstinaFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0003-2217-7053
Valdis PīrāgsFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.
Jelizaveta SokolovskaFaculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.ORCID 0000-0003-0448-8229
University of Latvia · LVPauls Stradiņš Clinical University Hospital · LV

Funding

European Regional Fund postdoctoral project No. 1.1.1.2/VIAA/3/19/525 "Intestinal inflammation as a potentially modifi-able risk factor for complications in type 1 diabetes"
6 · The paper itself

Abstract

The association of endotoxemia with metabolic syndrome (MS) and low-grade inflammation in type 1 diabetes (T1D) is little-studied. We investigated the levels of lipopolysaccharide (LPS), lipopolysaccharide-binding protein (LBP), endogenous anti-endotoxin core antibodies (EndoCAb IgG and IgM) and high-sensitivity C-reactive protein (hsCRP) in 74 T1D patients with different MS statuses and 33 control subjects. Within the T1D group, 31 patients had MS. These subjects had higher levels of LPS compared to patients without MS (MS 0.42 (0.35-0.56) or no MS 0.34 (0.3-0.4),

Indexed as

endogenous anti-endotoxin core antibodiesendotoxinlipopolysaccharide-binding proteinlow-grade inflammationmetabolic syndrometype 1 diabetes

Identifiers

PMID38137490
PMCPMC10740930
OpenAlexW4389547404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.