Evidence map›Paper›PMID 38139219›Full record

ArticleInternational journal of molecular sciences2023

Preclinical Evaluation of a Novel High-Affinity Radioligand [

Ekaterina Bezverkhniaia, Panagiotis Kanellopoulos, Ayman Abouzayed, Mariia Larkina, Maryam Oroujeni, Anzhelika Vorobyeva, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ekaterina BezverkhniaiaDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0001-7699-5719
Panagiotis KanellopoulosDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0002-0617-3936
Ayman AbouzayedDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Mariia LarkinaResearch Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634009 Tomsk, Russia.ORCID 0000-0003-1176-2441
Maryam OroujeniDepartment of Immunology, Genetics and Pathology, Uppsala University, 752 37 Uppsala, Sweden.ORCID 0000-0003-2660-9837
Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, 752 37 Uppsala, Sweden.ORCID 0000-0002-4778-3909
Ulrika RosenströmDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0002-0817-8140
Vladimir TolmachevDepartment of Immunology, Genetics and Pathology, Uppsala University, 752 37 Uppsala, Sweden.ORCID 0000-0002-6122-1734
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0001-6120-2683

Funding

Swedish Cancer Society 20 0815 PjSwedish Cancer Society CAN 21 1485 PjSwedish Cancer Society JIA 230650Swedish Research Council 2022-00556Swedish Research Council 2022-01519Tomsk Polytechnic University Priority-2030-NIP/IS-042-375-2023Uppsala University UFV-PA 2022/3323
6 · The paper itself

Abstract

Radionuclide imaging using radiolabeled inhibitors of prostate-specific membrane antigen (PSMA) can be used for the staging of prostate cancer. Previously, we optimized the Glu-urea-Lys binding moiety using a linker structure containing 2-napththyl-L-alanine and L-tyrosine. We have now designed a molecule that contains mercaptoacetyl-triglutamate chelator for labeling with Tc-99m (designated as BQ0413). The purpose of this study was to evaluate the imaging properties of [

Indexed as

ProstateProstatic NeoplasmsAnimalsAntigens, SurfaceGallium RadioisotopesGlutamate Carboxypeptidase IIHumansMaleMiceMice, Inbred BALB CTechnetiumAntigens, SurfaceGallium RadioisotopesGlutamate Carboxypeptidase IIPSMA-11TechnetiumBQ0413prostate cancerprostate-specific membrane antigenPSMAsingle-photon emission computed tomographytechnetium-99m

Identifiers

PMID38139219
PMCPMC10743726

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.