Evidence map›Paper›PMID 38141817›Full record

ReviewThe ocular surface2024

A closer look into the cellular and molecular biology of myoepithelial cells across various exocrine glands.

Olivier Mauduit, Vanessa Delcroix, Andrew Wong, Anastasiia Ivanova, Lindsey Miles, Hyun Soo Lee, Helen Makarenkova

Open access · greenAbstract readReview
In one paragraph

Review in The ocular surface, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Olivier MauduitDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Vanessa DelcroixDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Andrew WongDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Anastasiia IvanovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lindsey MilesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Hyun Soo LeeDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Helen MakarenkovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. Electronic address: hmakarenk@scripps.edu.
Scripps Research Institute · US

Funding

Regulation of plasminogen-dependent cell functions by the novel receptor, Plg-RKTR01HL081046 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI MILES, LINDSEY A · 2007 to 2024
$8.7M
Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Salivary gland ionocyte organization and function during homeostasis, repair, and diseaseR01DE031044 · NIDCR · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2021 to 2025
$3.0M
A Novel Plasminogen Receptor in Breast CancerR01CA166473 · NCI · TORREY PINES INST FOR MOLECULAR STUDIES · PI MILES, LINDSEY A, MUELLER, BARBARA MARIA · 2012 to 2016
$2.1M
NCI NIH HHS R01 CA166473NEI NIH HHS R01 EY026202NHLBI NIH HHS R01 HL081046NIDCR NIH HHS R01 DE031044
6 · The paper itself

Abstract

Myoepithelial cells (MECs) are a unique subset of epithelial cells that possess several smooth muscle cell characteristics, such as a high number of actin-myosin filaments and the ability to contract. These cells are primarily located around the secretory cells of exocrine glands, including the salivary, mammary, lacrimal, and sweat glands. Their primary functions involve the construction of the basement membrane and help with secretion of gland products through contraction. So far, no comparative analysis of MECs in different exocrine glands had ever evaluated their differences. In this review, we took advantage of the various publicly available scRNAseq data from mouse exocrine glands to identify their shared and unique characteristics. The aim of this review is to compare the role of MECs in maintaining healthy glandular function, their involvement in disease states, and their regenerative capacity, with a particular emphasis on the latest research findings in these areas.

Indexed as

Exocrine GlandsLacrimal ApparatusAnimalsEpithelial CellsMiceMolecular Biology

Identifiers

PMID38141817
PMCPMC10855576
OpenAlexW4390064496

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.