Evidence map›Paper›PMID 38145346›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Flexible Organic Photovoltaic-Powered Hydrogel Bioelectronic Dressing With Biomimetic Electrical Stimulation for Healing Infected Diabetic Wounds.

Yi-Wei Hu, Yu-Heng Wang, Fang Yang, Ding-Xin Liu, Guang-Hao Lu, Sheng-Tao Li, Zhi-Xiang Wei, Xiang Shen, Zhuang-De Jiang, Yi-Fan Zhao and 11 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Applications and prospects of biomaterials in diabetes management.Frontiers in bioengineering and biotechnology · 2025
    Review
  13. Advances in electrical stimulation for wound healing.Frontiers in bioengineering and biotechnology · 2025
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Yi-Wei HuHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.ORCID 0000-0001-6899-3545
Yu-Heng WangFaculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, 315211, P. R. China.ORCID 0000-0001-6394-1455
Fang YangHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.
Ding-Xin LiuState Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID 0000-0003-0910-2903
Guang-Hao LuState Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID 0000-0001-7829-7308
Sheng-Tao LiState Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID 0000-0002-1014-8004
Zhi-Xiang WeiCAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.ORCID 0000-0001-6188-3634
Xiang ShenThe Research Institute of Advanced Technologies, Ningbo University, Ningbo, 315211, P. R. China.
Zhuang-De JiangState Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Yi-Fan ZhaoState Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID 0000-0001-5634-5348
Qian PangHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.
Bai-Yang SongHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.
Ze-Wen ShiHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.
Shareen ShafiqueSchool of Physical Science and Technology, Ningbo University, Ningbo, 315211, P. R. China.
Kun ZhouShenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong Shenzhen, Shenzhen, 518172, P. R. China.ORCID 0000-0003-0782-3491
Xiao-Lian ChenPrintable Electronics Research Center & Nano-Device and Materials Division, Suzhou Institute of Nano-Tech and Nano-Bionics, Nano Chinese Academy of Sciences, Suzhou, 215123, P. R. China.
Wen-Ming SuPrintable Electronics Research Center & Nano-Device and Materials Division, Suzhou Institute of Nano-Tech and Nano-Bionics, Nano Chinese Academy of Sciences, Suzhou, 215123, P. R. China.ORCID 0000-0003-1721-1923
Jia-Wen JianFaculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo, 315211, P. R. China.ORCID 0000-0001-9505-755X
Ke-Qi TangInstitute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, 315211, P. R. China.
Tie-Long LiuOrthopaedic Oncology Center of Changzheng Hospital, Naval Medical University, Shanghai, 200003, P. R. China.ORCID 0009-0001-5500-4338
Ya-Bin ZhuHealth Science Center, Ningbo University, Ningbo, 315211, P. R. China.ORCID 0000-0002-9610-8707
Ningbo University · CNXi'an Jiaotong University · CNChinese Academy of Sciences · CNChinese University of Hong Kong, Shenzhen · CNNational Center for Nanoscience and Technology · CNShanghai Changzheng Hospital · CN

Funding

K.C. Wang Magna/Education Fund of Ningbo UniversityMajor Project of 2025 Sci & Tech Innovation of Ningbo 2020Z096National Natural Science Foundation of China 81972506National Natural Science Foundation of China 82172779National Natural Science Foundation of China U20A20121
6 · The paper itself

Abstract

Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption is limited by the requirement of additional extracorporeal devices to power ES-based wound dressings. In this study, a novel sandwich-structured photovoltaic microcurrent hydrogel dressing (PMH dressing) is designed for treating diabetic wounds. This innovative dressing comprises flexible organic photovoltaic (OPV) cells, a flexible micro-electro-mechanical systems (MEMS) electrode, and a multifunctional hydrogel serving as an electrode-tissue interface. The PMH dressing is engineered to administer ES, mimicking the physiological injury current occurring naturally in wounds when exposed to light; thus, facilitating wound healing. In vitro experiments are performed to validate the PMH dressing's exceptional biocompatibility and robust antibacterial properties. In vivo experiments and proteomic analysis reveal that the proposed PMH dressing significantly accelerates the healing of infected diabetic wounds by enhancing extracellular matrix regeneration, eliminating bacteria, regulating inflammatory responses, and modulating vascular functions. Therefore, the PMH dressing is a potent, versatile, and effective solution for diabetic wound care, paving the way for advancements in wireless ES wound dressings.

Indexed as

Diabetes MellitusHydrogelsBandagesBiomimeticsHumansProteomicsWound HealingHydrogelsconducting hydrogelelectrical stimulationflexible photovoltaic cellsproteomicswound dressing

Identifiers

PMID38145346
PMCPMC10933690
OpenAlexW4390195080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.