Evidence map›Paper›PMID 38150499›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.

Cheng-Guo Wu, Vijaya K Balakrishnan, Ronald A Merrill, Pankaj S Parihar, Kirill Konovolov, Yu-Chia Chen, Zhen Xu, Hui Wei, Ramya Sundaresan, Qiang Cui and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Jordan syndrome due toTranslational pediatrics · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Houge-Janssens syndrome.European journal of human genetics : EJHG · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Thirteen New Patients ofChildren (Basel, Switzerland) · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Cheng-Guo WuMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.ORCID 0000-0003-0514-6474
Vijaya K BalakrishnanMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.
Ronald A MerrillDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242.
Pankaj S PariharMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.ORCID 0000-0001-6196-6720
Kirill KonovolovChemistry Department, University of Wisconsin at Madison, Madison, WI 53706.
Yu-Chia ChenMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.
Zhen XuProtein and Crystallography Facility, University of Iowa, Iowa City, IA 52242.ORCID 0000-0001-8855-0565
Hui WeiThe Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027.ORCID 0000-0001-6777-1772
Ramya SundaresanMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.
Qiang CuiDepartment of Chemistry, Boston University, Boston, MA 02215.ORCID 0000-0001-6214-5211
Brian E WadzinskiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-2980-3697
Mark R SwingleDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688.
Alla MusiyenkoDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688.ORCID 0009-0001-0200-6532
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02215.ORCID 0000-0003-3438-5685
Richard E HonkanenDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688.ORCID 0000-0001-8487-8571
Aussie SuzukiMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.ORCID 0000-0001-7390-5116
Xuhui HuangBiophysics Program, University of Wisconsin at Madison, Madison, WI 53706.ORCID 0000-0002-7119-9358
Stefan StrackDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-6175-7280
Yongna XingMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, WI 53705.
University of Wisconsin–Madison · USUniversity of Iowa · USUniversity of South Alabama · USBoston Children's Hospital · USBoston University · USNew York Structural Biology Center · USVanderbilt University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Time resolved SAXS studies on the RP2/Arl3 complex pp.484-485P41GM103622 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2012 to 2020
$11.9M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Chromosome dynamics and organizations necessary for faithful chromosome segregationR35GM147525 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aussie Suzuki · 2022 to 2026
$2.5M
Structural basis of PP2A phosphatase diseasesR01GM145811 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Yongna Xing · 2023 to 2026
$1.4M
Structural and Cellular Choreography for Decommissioning and Recycling of PP2A HoloenzymesR01GM137090 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI XING, YONGNA · 2021 to 2024
$1.3M
NICHD NIH HHS P50 HD105351NIGMS NIH HHS P41 GM103622NIGMS NIH HHS R01 GM137090NIGMS NIH HHS R01 GM145811NIGMS NIH HHS R35 GM147525NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Intrinsically disordered regions (IDR) and short linear motifs (SLiMs) play pivotal roles in the intricate signaling networks governed by phosphatases and kinases. B56δ (encoded by

Indexed as

Protein Phosphatase 2HoloenzymesJordanMutationPhosphorylationHoloenzymesProtein Phosphatase 2cryogenic electron microscopyJordan’s syndromephosphatase

Identifiers

PMID38150499
PMCPMC10769853
OpenAlexW4390263917

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.