Evidence map›Paper›PMID 38150519›Full record

SynthesisArteriosclerosis, thrombosis, and vascular biology2024

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies.

Parveen K Garg, Harpreet S Bhatia, Tara S Allen, Tabitha Grainger, Anna L Pouncey, David Dichek, Renu Virmani, Jonathan Golledge, Matthew A Allison, Janet T Powell

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Ultrasound strain mapping of the non-aneurysmal abdominal aorta for detecting age-related aortic stiffening.International journal of cardiology. Cardiovascular risk and prevention · 2026
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  20. Non-Hypertensive Effects of Aldosterone.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Parveen K Garg *Division of Cardiology, University of Southern California, Keck School of Medicine, Los Angeles (G.P.).ORCID 0000-0002-6482-2711
Harpreet S Bhatia *Division of Cardiovascular Medicine, University of California San Diego (B.H., A.T., A.M.A.).
Tara S Allen *Division of Cardiovascular Medicine, University of California San Diego (B.H., A.T., A.M.A.).
Tabitha Grainger *Department of Surgery & Cancer, Imperial College London (G.T., P.A.-L., P.J.T.).
Anna L Pouncey *Department of Surgery & Cancer, Imperial College London (G.T., P.A.-L., P.J.T.).
David DichekDivision of Cardiology, Department of Medicine, University of Washington, Seattle (D.D.).ORCID 0000-0002-5224-2736
Renu VirmaniCVPath Institute, Gaithersburg, MD (V.R.).ORCID 0000-0003-1879-0015
Jonathan GolledgeQueensland Research Centre for Peripheral Vascular Disease, James Cook University and Townsville University Hospital, Australia (G.J.).ORCID 0000-0002-5779-8848
Matthew A AllisonDivision of Cardiovascular Medicine, University of California San Diego (B.H., A.T., A.M.A.).ORCID 0000-0003-0777-8272
Janet T PowellDepartment of Surgery & Cancer, Imperial College London (G.T., P.A.-L., P.J.T.).ORCID 0000-0002-3905-1468
Imperial College London · GBCVPath Institute · USFleet Science Center · USJames Cook University · AUSt Mary's Hospital · GBTwitter (United States) · USUniversity of California San Diego · USUniversity of Southern California · USUniversity of Washington · US

Funding

UCSD Integrated Cardiovascular Epidemiology FellowshipT32HL079891 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew A Allison · 2007 to 2026
$6.7M
Subclinical Renal Artery Atherosclerosis, Kidney Function and HypertensionR01DK080015 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2009 to 2011
$1.4M
Aspirin for Primary Prevention of Cardiovascular Disease in Patients with Elevated Lipoprotein(a)K08HL166962 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Harpreet Singh Bhatia · 2023 to 2026
$676k
NHLBI NIH HHS K08 HL166962NHLBI NIH HHS T32 HL079891NIDDK NIH HHS R01 DK080015
6 · The paper itself

Abstract

backgroundOne strategy to reduce the burden of cardiovascular disease is the early detection and treatment of atherosclerosis. This has led to significant interest in studies of subclinical atherosclerosis, using different phenotypes, not all of which are accurate reflections of the presence of asymptomatic atherosclerotic plaques. The aim of part 2 of this series is to provide a review of the existing literature on purported measures of subclinical disease and recommendations concerning which tests may be appropriate in the prevention of incident cardiovascular disease.

methodsWe conducted a critical review of measurements used to infer the presence of subclinical atherosclerosis in the major conduit arteries and focused on the predictive value of these tests for future cardiovascular events, independent of conventional cardiovascular risk factors, in asymptomatic people. The emphasis was on studies with >10 000 person-years of follow-up, with meta-analysis of results reporting adjusted hazard ratios (HRs) with 95% CIs. The arterial territories were limited to carotid, coronary, aorta, and lower limb arteries.

resultsIn the carotid arteries, the presence of plaque (8 studies) was independently associated with future stroke (pooled HR, 1.89 [1.04-3.44]) and cardiac events (7 studies), with a pooled HR, 1.77 (1.19-2.62). Increased coronary artery calcium (5 studies) was associated with the risk of coronary heart disease events, pooled HR, 1.54 (1.07-2.07) and increasing severity of calcification (by Agaston score) was associated with escalation of risk (13 studies). An ankle/brachial index (ABI) of <0.9, the pooled HR for cardiovascular death from 7 studies was 2.01 (1.43-2.81). There were insufficient studies of either, thoracic or aortic calcium, aortic diameter, or femoral plaque to synthesize the data based on consistent reporting of these measures.

conclusionsThe presence of carotid plaque, coronary artery calcium, or abnormal ankle pressures seems to be a valid indicator of the presence of subclinical atherosclerosis and may be considered for use in biomarker, Mendelian randomization and similar studies.

Indexed as

AtherosclerosisCardiovascular DiseasesCoronary Artery DiseasePlaque, AtheroscleroticBiomarkersCalciumHumansMendelian Randomization AnalysisRisk FactorsBiomarkersCalciumaortaatherosclerosiscarotid arteriesmyocardial infarctionphenotype

Identifiers

PMID38150519
PMCPMC10753091
OpenAlexW4388864140

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.