Evidence map›Paper›PMID 38153877›Full record

ArticleDiabetes care2024

Plasma miRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Pandora L Wander, Theo K Bammler, James W MacDonald, Sengeo Srinouanprachanh, Edward J Boyko, Daniel A Enquobahrie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pandora L WanderVeterans Affairs Puget Sound Health Care System, Seattle, WA.ORCID 0000-0003-3671-1464
Theo K BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA.
James W MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA.
Sengeo SrinouanprachanhDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA.
Edward J BoykoVeterans Affairs Puget Sound Health Care System, Seattle, WA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, WA.
University of Washington · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · UNIVERSITY OF WASHINGTON · 1995 to 2025
$10.2M
NIDDK NIH HHS K08 DK103945NIDDK NIH HHS K08DK103945NIDDK NIH HHS R03 DK122100
6 · The paper itself

Abstract

objectiveTo identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D). RESEARCH DESIGN AND

methodsWe examined whether a panel of miRNAs could predict treatment failure in training/test data sets among participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study (N = 209). We also examined whether individual miRNAs were associated with treatment failure.

resultsParticipants were age 14.5 years, and 62% were female. A panel of miRNAs did not predict treatment failure. However, for each doubling, miR-4306 was associated with a 12% decrease (P = 0.040) and miR-483-3p was marginally associated with a 12% increase (P = 0.080) in failure independently of sex, race/ethnicity, BMI, Tanner stage, HbA1c, maternal diabetes, oral disposition index, and treatment arm. The addition of both miRNAs improved model fit (log likelihood without vs. with miRNAs -360.3 vs. -363.5; P = 0.040).

conclusionsmiR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2MicroRNAsAdolescentEthnicityFemaleHumansMalePregnancyTreatment FailureMicroRNAsMIRN4306 microRNA, human

Identifiers

PMID38153877
PMCPMC10909680
OpenAlexW4390335519

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.