ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07651787 (Neurovascular and Mitochondrial Mechanisms of Transcranial Photobiomodulation in Vascular Mild Cognitive Impairment), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurovascular and Mitochondrial Mechanisms of Transcranial Photobiomodulation in Vascular Mild Cognitive Impairment
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Chronic Cerebral Hypoxia and Cognitive Impairment: A Systematic Review and Meta-Analysis Based on Chronic Mountain Sickness, Anemia, Chronic Obstructive Pulmonary Disease, and Obstructive Sleep Apnea.CNS neuroscience & therapeutics · 2026Pooled it
- Photobiomodulation in the aging brain: a systematic review from animal models to humans.GeroScience · 2024Pooled it
- Effects of NADThe Journal of pharmacology and experimental therapeutics · 2025Trial
- Workplace stress and healthy aging: assessment strategies, research hypotheses, and pilot insights from the Semmelweis study.GeroScience · 2026Review
- Machine learning assessment of cognitive reserve using functional near-infrared spectroscopy in older adults with cognitive frailty.GeroScience · 2026Article
- Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Connectome-Guided Personalization of Optimal TDCS Intervention Selection in Alzheimer's Disease: A Modeling Study.eNeuro · 2026Article
- Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross-sectional study.Psychiatry and clinical neurosciences · 2026Article
- Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging.Research square · 2026Article
- Contributions of vascular ageing to late-onset Alzheimer's disease.Experimental physiology · 2026Review
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Distinct neural signatures of phonemic and semantic verbal fluency: a double dissociation in cortical activation and functional connectivity revealed by fNIRS.Neurophotonics · 2026Article
- Neurovascular decoupling: An early indicator of cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Super-resolution ultrasound imaging indirectly reveals neurovascular uncoupling in substantia nigra of a Parkinson's disease model.NPJ Parkinson's disease · 2026Article
- Transcranial magnetic stimulation from healthy brain aging to Alzheimer's disease: a review on mechanisms, therapeutic potential, and future clinical directions.Frontiers in aging neuroscience · 2026Review
- The neurovascular coupling basis of cognitive impairment in patients with H-type hypertension: a cross-modal study using resting-state fMRI and arterial spin labeling.Frontiers in medicine · 2026Article
- Chronic impairment of neurovascular coupling and cognitive decline in young survivors of severe traumatic brain injury.GeroScience · 2025Article
- Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility.The Journal of pharmacology and experimental therapeutics · 2025Review
- Age-Related Alterations of Cerebral Autoregulation.Life (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 7 institutions in 2 countries.
Peter MukliOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0003-4355-8103
Camila B PintoOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0003-2820-8703
Cameron D OwensOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-5020-2810
Tamas CsipoOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0003-2639-2404
Agnes LipeczOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.
Zsofia SzarvasOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-0022-5053
Anna PeterfiOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-2455-5823
Ana Clara da Costa Pinaffi LangleyOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.
Jordan HoffmeisterDepartment of Cardiology, Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.ORCID 0000-0002-0227-1926
Frigyes Samuel RaczDepartment of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary.ORCID 0000-0001-9077-498X
Jonathan W PerryOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-1474-4858
Stefano TarantiniOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0001-5627-1430
Ádám Nyúl-TóthOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0001-6611-9539
Farzaneh A SorondDepartment of Neurology, Division of Stroke and Neurocritical Care, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL, 60611, USA.ORCID 0000-0002-6127-0739
Yuan YangStephenson School of Biomedical Engineering, The University of Oklahoma, Tulsa, OK, 73019, USA.ORCID 0000-0003-2442-3713
Judith A JamesOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-9574-7355
Angelia C KirkpatrickVeterans Affairs Medical Center, Oklahoma City, OK, 73104, USA.ORCID 0000-0003-2500-6380
Calin I ProdanVeterans Affairs Medical Center, Oklahoma City, OK, 73104, USA.
Peter TothInternational Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, H-1085, Hungary.
Juliette GalindoDepartment of Cardiology, Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.ORCID 0000-0002-1606-3765
Andrew W GardnerDepartment of Physical Medicine and Rehabilitation, Penn State College of Medicine, 700 HMC Crescent Road, Hershey, PA, 17033, USA.ORCID 0000-0001-7721-5438
William E SonntagOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0003-1850-2407
Anna CsiszarOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0003-4842-6660
Zoltan UngvariOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-6035-6039
Andriy YabluchanskiyOklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.ORCID 0000-0002-9648-7161
Semmelweis University · HUUniversity of Oklahoma Health Sciences Center · USNorthwestern University · USUniversity of Debrecen · HUVeterans Health Administration · USOklahoma Medical Research Foundation · USPenn State Milton S. Hershey Medical Center · US
Funding
Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI JUDITH A JAMES · 2013 to 2026
$68.2MTissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1MVisualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Sreemathi Logan · 2019 to 2026
$17.8MTargeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew John Hart · 2015 to 2026
$13.9MCerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & ResilienceR01NS085002 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FARZANEH A SOROND · 2014 to 2026
$3.8MGEROSCIENCE TRAINING PROGRAM IN OKLAHOMAT32AG052363 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Benjamin Francis Miller, William Edmund Sonntag · 2017 to 2026
$3.6MEffects of NAD restoration on neurovascular coupling in community dwelling older adultsR01AG075834 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Aikaterini Thanou, Andriy Yabluchanskiy · 2022 to 2026
$3.2MCerebral microhemorrhages and gait dysfunction in agingR01AG055395 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2017 to 2025
$2.3MAge-related vascular cognitive impairment: role of endothelial senescenceR01AG068295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2020 to 2024
$1.8MRadiation-induced astrocyte dysfunction and cognitive declineR01NS100782 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI UNGVARI, ZOLTAN ISTVAN · 2018 to 2022
$1.7MShift from Unilateral to Bilateral Sensory-Motor Connectivity in Chronic Hemiparetic StrokeR01HD109157 · NICHD · UNIVERSITY OF OKLAHOMA · PI Yuan Yang · 2022 to 2026
$1.7MChemotherapy-induced vascular cognitive impairment: role of endothelial senescenceR01CA255840 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2021 to 2025
$1.6MAmerican Heart Association-American Stroke Association 932980American Heart Association-American Stroke Association 966924BLRD VA I01 BX005592CSRD VA I01 CX000340CSRD VA I01 CX002578NCI NIH HHS P30 CA225520NCI NIH HHS R01 CA255840NCI NIH HHS R01CA255840NIA NIH HHS K01 AG073614NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG055395NIA NIH HHS R01 AG068295NIA NIH HHS R01 AG075834NIA NIH HHS R03 AG070479NIA NIH HHS RF1 AG072295NIA NIH HHS T32 AG052363NICHD NIH HHS R01 HD109157NIGMS NIH HHS P20 GM125528NIGMS NIH HHS U54 GM104938NIH HHSNINDS NIH HHS R01 NS085002NINDS NIH HHS R01 NS100782NINDS NIH HHS R01NS100782NINDS NIH HHS RF1 NS085002
Abstract
Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.
Indexed as
Cognitive DysfunctionNeurovascular CouplingAgedBrainFrontal LobeHumansagingcognitive declinefunctional connectivityfunctional near-infrared spectroscopyneurovascular coupling
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LicenceCC BY
Read underepoch 390
Registered trials
NCT07651787ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.