ArticlePhysical and engineering sciences in medicine2024
Flow-induced high frequency vascular wall vibrations in an arteriovenous fistula: a specific stimulus for stenosis development?
Article in Physical and engineering sciences in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Flow-Induced High-frequency Vascular Wall Vibrations: A New Mechanobiological Stimulus for Vascular Remodeling?Annals of biomedical engineering · 2026Article
- The Role of High-Frequency Wall Vibrations in Adverse Vascular Remodeling of Arteriovenous Fistula for Hemodialysis.Kidney360 · 2026Article
- Post-stenotic arterio-venous fistula vein wall flutter as a potential ultrasound sign of significant stenosis - three case reports.BMC nephrology · 2026Article
- Potential biomarkers and regulatory pathways associated with arteriovenous fistula stenosis in end-stage renal disease: an analysis based on transcriptomic profiling.BMC nephrology · 2026Article
- Nonlinear anisotropic constitutive description of the human basilic vein and comparison with the vein of the lower limb.Biomechanics and modeling in mechanobiology · 2025Article
- In Silico, Patient-Specific Assessment of Local Hemodynamic Predictors and Neointimal Hyperplasia Localisation in an Arteriovenous Graft.Annals of biomedical engineering · 2025Article
- High-Frequency Vessel Wall Vibrations Associate With Stenosis Formation and Arteriovenous Fistula Failure.Kidney medicine · 2025Article
- Tissue metabolomics reveals metabolic dysregulation associated with intimal hyperplasia in arteriovenous fistula stenosis.Frontiers in physiology · 2025Article
- Fluid-structure interaction in a follow-up study of arterio-venous fistula maturation.Scientific reports · 2024Article
- Effects of high-frequency mechanical stimuli on flow related vascular cell biology.The International journal of artificial organs · 2024Review
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Hemodialysis is the lifeline for nearly three million end stage renal disease patients worldwide. Native arteriovenous fistula (AVF) is the preferred vascular access, but 40% fail within 1 year. We recently demonstrated that AVFs harbour transitional flows and the goal of the present study was to investigate whether the associated high-frequency pressure fluctuations could promote vibrations within the vascular wall. We acquired MRI images and flow rates immediately after surgery in one patient and generated a 3D patient-specific model. High-fidelity fluid structure interaction simulations revealed the presence of wall vibrations in distinct frequency bands up to 200 Hz and amplitude of 200 μm. A sensitivity analysis to assess the impact of flow rates, and vascular wall stiffness and thickness, changes that typically occur during AVF maturation, confirmed the robustness of the results. Interestingly, the vibrations were always predominant at the anastomosis floor and on the inner venous side, which correlates with typical stenotic regions. As studies seeking to correlate aberrant stresses and vascular remodelling have been largely inconclusive, the focal colocalization between vibrations and stenosis may suggest an unknown mechanobiological process between high-frequency mechanical stresses within the vascular wall and adverse vascular remodelling.
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