Evidence map›Paper›PMID 38157849›Full record

ReviewStem cell reports2024

A short history of pluripotent stem cells markers.

Peter W Andrews, Paul J Gokhale

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  15. Standardization and quality assessment for human intestinal organoids.Frontiers in cell and developmental biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter W AndrewsThe School of Biosciences, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Paul J GokhaleThe School of Biosciences, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. Electronic address: p.w.andrews@sheffield.ac.uk.
University of Sheffield · GB

Funding

Medical Research Council MR/R015724/1Medical Research Council MR/V002163/1
6 · The paper itself

Abstract

The expression of one or more of a small number of molecules, typically cell surface-associated antigens, or transcription factors, is widely used for identifying pluripotent stem cells (PSCs) or for monitoring their differentiation. However, none of these marker molecules are uniquely expressed by PSCs and all are expressed by stem cells that have lost the ability to differentiate. Consequently, none are indicators of pluripotency, per se. Here we summarize the nature and characteristics of several markers that are in wide use, including the cell surface antigens, stage-specific embryonic antigen (SSEA)-1, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, GCTM2, and the transcription factors POUF5/OCT4, NANOG, and SOX2, highlighting issues that must be considered when interpreting data about their expression on putative PSCs.

Indexed as

Pluripotent Stem CellsAntigens, SurfaceCell DifferentiationLewis X AntigenOctamer Transcription Factor-3Transcription FactorsAntigens, SurfaceLewis X AntigenOctamer Transcription Factor-3Transcription Factors

Identifiers

PMID38157849
PMCPMC10828816
OpenAlexW4390338918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.