Evidence map›Paper›PMID 38159267›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Umbrella review and Delphi study on modifiable factors for dementia risk reduction.

Colin Rosenau, Sebastian Köhler, Lion M Soons, Kaarin J Anstey, Carol Brayne, Henry Brodaty, Knut Engedal, Francesca R Farina, Mary Ganguli, Gill Livingston and 10 more

Registry-linked trialOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06832761 (Secondary Prevention of Dementia in Memory Clinics), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
31.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06832761 narecruitingnot on this mapstarted 2025, after this paper: background citation

Secondary Prevention of Dementia in Memory Clinics: Implementation and (Cost-)Effectiveness of an Integrated Lifestyle Intervention

TypeinterventionalSponsorMaastricht University Medical CenterRan2025 to 2027Enrolled300ConditionsLifestyle Intervention, Lifestyle Risk Reduction, Cognitive Decline, DementiaArmsPersonalized lifestyle intervention
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  3. Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  16. Self-Efficacy is Key: Examining the Role of Motivation to Engage in Healthy Lifestyle Behaviors for Dementia Prevention in Midlife.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 8 countries.

Colin RosenauAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Sebastian KöhlerAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Lion M SoonsAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Kaarin J AnsteySchool of Psychology, University of New South Wales, Kensington, New South Wales, Australia.
Carol BrayneCambridge Public Health, University of Cambridge, Cambridge, UK.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Knut EngedalNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Francesca R FarinaFeinberg School of Medicine, Department of Medical Social Sciences, Northwestern University, Chicago, Illinois, USA.
Mary GanguliDepartments of Psychiatry, Neurology, and Epidemiology, School of Medicine and School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.
Constantine G LyketsosRichman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Johns Hopkins Bayview, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Francesca MangialascheDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Laura E MiddletonDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Marcel G M Olde RikkertDepartment of Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Ruth PetersUNSW Ageing Futures Institute, Kensington, New South Wales, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Nikolaos Scarmeas1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Geir SalbaekNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Martin P J van BoxtelAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Kay DeckersAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands.
Maastricht University · NLUNSW Sydney · AUJohns Hopkins University · USKarolinska University Hospital · SENational and Kapodistrian University of Athens · GRNorthwestern University · USOslo University Hospital · NORadboud University Nijmegen · NLSykehuset i Vestfold · NOUniversity College London · GBUniversity of Cambridge · GBUniversity of Pittsburgh · USUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 2013 systematic review and Delphi consensus study identified 12 modifiable risk and protective factors for dementia, which were subsequently merged into the "LIfestyle for BRAin health" (LIBRA) score. We systematically evaluated whether LIBRA requires revision based on new evidence. To identify modifiable risk and protective factors suitable for dementia risk reduction, we combined an umbrella review of systematic reviews and meta-analyses with a two-round Delphi consensus study. The review of 608 unique primary studies and opinions of 18 experts prioritized six modifiable factors: hearing impairment, social contact, sleep, life course inequalities, atrial fibrillation, and psychological stress. Based on expert ranking, hearing impairment, social contact, and sleep were considered the most suitable candidates for inclusion in updated dementia risk scores. As such, the current study shows that dementia risk scores need systematic updates based on emerging evidence. Future studies will validate the updated LIBRA score in different cohorts. HIGHLIGHTS: An umbrella review was combined with opinions of 18 dementia experts. Various candidate targets for dementia risk reduction were identified. Experts prioritized hearing impairment, social contact, and sleep. Re-assessment of dementia risk scores is encouraged. Future work should evaluate the predictive validity of updated risk scores.

Indexed as

Delphi TechniqueDementiaRisk Reduction BehaviorHearing LossHumansLife StyleRisk FactorsSleepbrain healthcognitive declinecognitive impairmentDelphi studydementiaetiological risk factorshearing impairmentlifestylepreventionprotective factorsrisk predictionrisk reductionsleepsocial contactumbrella review

Identifiers

PMID38159267
PMCPMC10984497
OpenAlexW4390443949

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.