Evidence map›Paper›PMID 38159849›Full record

ArticleThe Journal of biological chemistry2024

Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.

Cody Aplin, Richard A Cerione

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Cody AplinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Richard A CerioneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA; Department of Molecular Medicine, Cornell University, Ithaca, New York, USA. Electronic address: rac1@cornell.edu.
Cornell University · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
TRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMST32GM008267 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1988 to 2021
$9.6M
Probing the molecular mechanisms that regulate key steps in the GPCR-sensory response pathway responsible for vision in dim lightR01EY034867 · NEI · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2023 to 2026
$1.5M
NEI NIH HHS R01 EY034867NIGMS NIH HHS P30 GM124166NIGMS NIH HHS T32 GM008267
6 · The paper itself

Abstract

Phototransduction in retinal rods occurs when the G protein-coupled photoreceptor rhodopsin triggers the activation of phosphodiesterase 6 (PDE6) by GTP-bound alpha subunits of the G protein transducin (Gα

Indexed as

Cyclic Nucleotide Phosphodiesterases, Type 6Models, MolecularTransducin1-Methyl-3-isobutylxanthineAnimalsCatalytic DomainCattleEnzyme ActivationGuanosine TriphosphateLipid BilayersProtein BindingProtein Structure, QuaternaryRecombinant ProteinsRetinal Rod Photoreceptor Cells1-Methyl-3-isobutylxanthineCyclic Nucleotide Phosphodiesterases, Type 6Guanosine TriphosphateLipid BilayersRecombinant ProteinsTransducincryoelectron microscopyG proteinphosphodiesterasephototransductionsignal transductionstructural biology

Identifiers

PMID38159849
PMCPMC10838916
OpenAlexW4390326878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.