Evidence map›Paper›PMID 38166599›Full record

ArticleJournal of neurodevelopmental disorders2024

Degraded inferior colliculus responses to complex sounds in prenatally exposed VPA rats.

Yuko Tamaoki, Varun Pasapula, Collin Chandler, Michael S Borland, Olayinka I Olajubutu, Liza S Tharakan, Crystal T Engineer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuko TamaokiSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA. Yuko.Tamaoki@utdallas.edu.ORCID 0000-0002-5102-9167
Varun PasapulaSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Collin ChandlerSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Michael S BorlandSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Olayinka I OlajubutuSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Liza S TharakanSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Crystal T EngineerSchool of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Road BSB11, Richardson, TX, 75080, USA.
Texas Biomedical Research Institute · USThe University of Texas at Dallas · US

Funding

Enhancing Speech Processing In A Rat Model Of Autism Using Vagus Nerve StimulationR01DC017480 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI ENGINEER, CRYSTAL T · 2019 to 2023
$2.0M
NIDCD NIH HHS R01 DC017480NIDCD NIH HHS R01DC017480
6 · The paper itself

Abstract

backgroundIndividuals with autism spectrum disorders (ASD) often exhibit altered sensory processing and deficits in language development. Prenatal exposure to valproic acid (VPA) increases the risk for ASD and impairs both receptive and expressive language. Like individuals with ASD, rodents prenatally exposed to VPA exhibit degraded auditory cortical processing and abnormal neural activity to sounds. Disrupted neuronal morphology has been documented in earlier processing areas of the auditory pathway in VPA-exposed rodents, but there are no studies documenting early auditory pathway physiology. Therefore, the objective of this study is to characterize inferior colliculus (IC) responses to different sounds in rats prenatally exposed to VPA compared to saline-exposed rats.

methodsIn vivo extracellular multiunit recordings from the inferior colliculus were collected in response to tones, speech sounds, and noise burst trains.

resultsOur results indicate that the overall response to speech sounds was degraded in VPA-exposed rats compared to saline-exposed controls, but responses to tones and noise burst trains were unaltered.

conclusionsThese results are consistent with observations in individuals with autism that neural responses to complex sounds, like speech, are often altered, and lays the foundation for future studies of potential therapeutics to improve auditory processing in the VPA rat model of ASD.

Indexed as

Autism Spectrum DisorderInferior ColliculiAnimalsAuditory PerceptionFemalePregnancyRatsRats, Sprague-DawleyValproic AcidValproic AcidAuditory processingAutismInferior colliculusValproic acid

Identifiers

PMID38166599
PMCPMC10759431
OpenAlexW4390506520

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.