Evidence map›Paper›PMID 38166648›Full record

ArticleJournal of neurodevelopmental disorders2024

White matter microstructure of children with sensory over-responsivity is associated with affective behavior.

Jamie Wren-Jarvis, Rachel Powers, Maia C Lazerwitz, Jaclyn Xiao, Lanya T Cai, Hannah L Choi, Annie Brandes-Aitken, Robyn Chu, Kaitlyn J Trimarchi, Rafael D Garcia and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jamie Wren-JarvisDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA.
Rachel PowersDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA.
Maia C LazerwitzCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA.
Jaclyn XiaoDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA.
Lanya T CaiDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA.
Hannah L ChoiDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA.
Annie Brandes-AitkenCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA.
Robyn ChuCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA.
Kaitlyn J TrimarchiCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA.
Rafael D GarciaCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA.
Mikaela A RoweDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Mary C SteeleLifetime Neurodevelopmental Care Center, San Rafael, CA, USA.
Elysa J MarcoCortica Healthcare, 4000 Civic Center Dr., Suite 100, San Rafael, CA, 94903, USA. emarco@corticacare.com.
Pratik MukherjeeDepartment of Radiology & Biomedical Imaging, University of California, UCSF, 185 Berry St, Suite 350, Box 0946, San Francisco, CA, 94143-0946, USA. pratik.mukherjee@gmail.com.ORCID 0000-0001-7473-7409
Berry (United States) · USNeuroDevelopment Center · USUniversity of California, San Francisco · USUniversity of Colorado Boulder · US

Funding

Neural Mechanisms of Sensory OverResponsivityR01MH116950 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCO, ELYSA JILL, MUKHERJEE, PRATIK · 2019 to 2023
$2.7M
NIH HHS R01 MH116950NIMH NIH HHS R01 MH116950
6 · The paper itself

Abstract

backgroundSensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression.

methodsChildren ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR.

resultsGlobal WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts.

conclusionWhite matter microstructure is related to affective behavior in children with SOR.

Indexed as

White MatterCerebellumChildDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleDepressionDTIMRISensory over-responsivitySensory processing disorderSomatizationWhite matter

Identifiers

PMID38166648
PMCPMC10759342
OpenAlexW4390493029

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.