Evidence map›Paper›PMID 38168281›Full record

ArticlebioRxiv : the preprint server for biology2023

Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates.

Rebecca L Wilson, Jenna Kropp Schmidt, Baylea N Davenport, Emily Ren, Logan T Keding, Sarah A Shaw, Michele L Schotzko, Kathleen M Antony, Heather A Simmons, Thaddeus G Golos and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rebecca L WilsonORCID 0000-0002-3867-7784
Jenna Kropp Schmidt
Baylea N Davenport
Emily Ren
Logan T Keding
Sarah A Shaw
Michele L Schotzko
Kathleen M Antony
Heather A Simmons
Thaddeus G Golos
Helen N Jones
University of Wisconsin–Madison · USUniversity of Florida · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH HHS P51 OD011106
6 · The paper itself

Abstract

Background: Currently, there are no placenta-targeted treatments to alter the Methods: Pregnant macaques underwent ultrasound-guided intraplacental injections of nanoparticles ( Findings: Fluorescent microscopy and in situ hybridization confirmed placental uptake and transgene expression in villous syncytiotrophoblast. No off-target expression was observed in maternal and fetal tissues. Histopathological assessment of the placenta recorded observations not necessarily related to the Interpretation: Maternal toxicity profile analysis and lack of adverse reaction to nanoparticle-mediated Funding: National Institutes of Health, and Wisconsin National Primate Research Center.

Identifiers

PMID38168281
PMCPMC10760006
OpenAlexW4381336684

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.