Evidence map›Paper›PMID 38168292›Full record

ArticlebioRxiv : the preprint server for biology2024

Assessment of Neurovascular Uncoupling:

Kristen Onos, Peter B Lin, Ravi S Pandey, Scott A Persohn, Charles P Burton, Ethan W Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E Foley, Gregory W Carter and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kristen OnosThe Jackson Laboratory, Bar Harbor, ME 04609 USA.
Peter B LinStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.
Ravi S PandeyThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA.
Scott A PersohnStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.
Charles P BurtonStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.
Ethan W MinerStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.
Kierra EldridgeStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.
Jonathan Nyandu KanyindaThe Jackson Laboratory, Bar Harbor, ME 04609 USA.
Kate E FoleyThe Jackson Laboratory, Bar Harbor, ME 04609 USA.
Gregory W CarterThe Jackson Laboratory, Bar Harbor, ME 04609 USA.ORCID 0000-0002-2834-8186
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME 04609 USA.ORCID 0000-0003-0565-6474
Paul R TerritoStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.ORCID 0000-0003-0460-332X

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Modulation of TNFα as a Treatment for Alzheimer's Disease and Related DementiaR21AG078575 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI HOWELL, GARETH R, TERRITO, PAUL RICHARD · 2022 to 2022
$469k
NIA NIH HHS R21 AG078575NIA NIH HHS U54 AG054345NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein ε4 (

methodsPET imaging was used to assess metabolism-perfusion in both sexes of aging C57BL/6J, and h

resultsAll h DISCUSSION: This work highlights

Indexed as

Alzheimer’s diseaseAPOEMetabolismPerfusionUncoupling

Identifiers

PMID38168292
PMCPMC10760108

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.