Evidence map›Paper›PMID 38168421›Full record

ArticlebioRxiv : the preprint server for biology2023

miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.

Theresa M Welle, Dipen Rajgor, Joshua D Garcia, Dean Kareemo, Sarah M Zych, Sara E Gookin, Tyler P Martinez, Mark L Dell'Acqua, Christopher P Ford, Matthew J Kennedy and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Theresa M WelleDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Dipen RajgorDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Joshua D GarciaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Dean KareemoDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Sarah M ZychDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Sara E GookinDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Tyler P MartinezDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Matthew J KennedyDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045.ORCID 0000-0002-4762-7201
University of Colorado Anschutz Medical Campus · USZero to Three · US

Funding

Novel approaches for interrogating and manipulating synaptic function, structure and plasticityR35NS116879 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Matthew J Kennedy · 2020 to 2026
$4.0M
Encoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5M
Regulation of striatal acetylcholine transmission by cholinergic interneuronsR01NS095809 · NINDS · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2016 to 2024
$3.4M
L-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription CouplingR01MH123700 · NIMH · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2021 to 2025
$2.8M
Local translation mechanisms to control inhibitory synaptic plasticityR01MH128199 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2022 to 2025
$2.5M
Neuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1M
Nanoscale organization of the inhibitory synapse during synaptic plasticityR01MH119154 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2020 to 2024
$2.0M
Mapping somatodendritic circuits of midbrain dopamine neuronsF30DA048543 · NIDA · UNIVERSITY OF COLORADO DENVER · PI ZYCH, SARAH · 2019 to 2022
$156k
Investigating the synaptic trafficking of endogenous AMPARsF31NS130979 · NINDS · UNIVERSITY OF COLORADO DENVER · PI KAREEMO, DEAN · 2023 to 2025
$93k
Understanding the temporal regulation of inhibitory synapse depression and elimination in the context of cerebral ischemiaF99NS120640 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GARCIA, JOSHUA DAYLON · 2021 to 2022
$72k
NIDA NIH HHS F30 DA048543NIDA NIH HHS R01 DA035821NIMH NIH HHS R01 MH119154NIMH NIH HHS R01 MH123700NIMH NIH HHS R01 MH128199NINDS NIH HHS F31 NS130979NINDS NIH HHS F99 NS120640NINDS NIH HHS R01 NS095809NINDS NIH HHS R35 NS116879NINDS NIH HHS T32 NS099042
6 · The paper itself

Abstract

Activity-dependent protein synthesis is crucial for many long-lasting forms of synaptic plasticity. However, our understanding of the translational mechanisms controlling inhibitory synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP) enhances postsynaptic clusters of GABA

Identifiers

PMID38168421
PMCPMC10760056
OpenAlexW4389639098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.