Evidence map›Paper›PMID 38169244›Full record

ArticleBrain, behavior, and immunity2024

Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study.

Deepthi Bannai, Martin Reuter, Rachal Hegde, Dung Hoang, Iniya Adhan, Swetha Gandu, Sovannarath Pong, Nick Raymond, Victor Zeng, Yoonho Chung and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Manual Segmentation of the Human Choroid Plexus Using Brain MRI.Journal of visualized experiments : JoVE · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Deepthi BannaiDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Martin ReuterGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
Rachal HegdeDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dung HoangDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Iniya AdhanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Swetha GanduDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Sovannarath PongDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nick RaymondDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Victor ZengDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Yoonho ChungDepartment of Psychology, Yale University, New Haven, CT, USA.
George HeDepartment of Psychology, Yale University, New Haven, CT, USA.
Daqiang SunSemel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, Los Angeles, CA, USA.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, UC Irvine, Irvine, CA, USA.
Jean AddingtonHotchkins Brain Institute, Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
Carrie E BeardenSemel Institute for Neuroscience and Human Behavior and Department of Psychology, UCLA, Los Angeles, CA, USA.
Kristin CadenheadDepartment of Psychiatry, UCSD, San Diego, CA, USA.
Barbara CornblattDepartment of Psychiatry, Zucker Hillside Hospital, Queens, NY, USA.
Daniel H MathalonDepartment of Psychiatry, UCSF, San Francisco, CA, USA.
Thomas McGlashanDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Clark JeffriesRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
William StoneDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Ming TsuangDepartment of Psychiatry, UCSD, San Diego, CA, USA.
Elaine WalkerDepartment of Psychology, Yale University, New Haven, CT, USA.
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale University, New Haven, CT, USA.
Diana PerkinsRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Matcheri KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Paulo LizanoDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: lizanopl@gmail.com.

Funding

1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
NIMH NIH HHS U01 MH081902
6 · The paper itself

Abstract

backgroundChoroid plexus (ChP) enlargement exists in first-episode and chronic psychosis, but whether enlargement occurs before psychosis onset is unknown. This study investigated whether ChP volume is enlarged in individuals with clinical high-risk (CHR) for psychosis and whether these changes are related to clinical, neuroanatomical, and plasma analytes.

methodsClinical and neuroimaging data from the North American Prodrome Longitudinal Study 2 (NAPLS2) was used for analysis. 509 participants (169 controls, 340 CHR) were recruited. Conversion status was determined after 2-years of follow-up, with 36 psychosis converters. The lateral ventricle ChP was manually segmented from baseline scans. A subsample of 31 controls and 53 CHR had plasma analyte and neuroimaging data.

resultsCompared to controls, CHR (d = 0.23, p = 0.017) and non-converters (d = 0.22, p = 0.03) demonstrated higher ChP volumes, but not in converters. In CHR, greater ChP volume correlated with lower cortical (r = -0.22, p < 0.001), subcortical gray matter (r = -0.21, p < 0.001), and total white matter volume (r = -0.28,p < 0.001), as well as larger lateral ventricle volume (r = 0.63,p < 0.001). Greater ChP volume correlated with makers functionally associated with the lateral ventricle ChP in CHR [CCL1 (r = -0.30, p = 0.035), ICAM1 (r = 0.33, p = 0.02)], converters [IL1β (r = 0.66, p = 0.004)], and non-converters [BMP6 (r = -0.96, p < 0.001), CALB1 (r = -0.98, p < 0.001), ICAM1 (r = 0.80, p = 0.003), SELE (r = 0.59, p = 0.026), SHBG (r = 0.99, p < 0.001), TNFRSF10C (r = 0.78, p = 0.001)].

conclusionsCHR and non-converters demonstrated significantly larger ChP volumes compared to controls. Enlarged ChP was associated with neuroanatomical alterations and analyte markers functionally associated with the ChP. These findings suggest that the ChP may be a key an important biomarker in CHR.

Indexed as

Choroid PlexusPsychotic DisordersHumansLongitudinal StudiesNeuroimagingPhenotypeChoroid plexusClinical high risk for psychosisInflammationLateral ventricle

Identifiers

PMID38169244
PMCPMC10932816

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.