Evidence map›Paper›PMID 38172621›Full record

ReviewNature microbiology2024

Toxoplasma protein export and effector function.

Simona Seizova, Abel Ferrel, John Boothroyd, Christopher J Tonkin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. A Suite of EightbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Role ofInternational journal of molecular sciences · 2025
    Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Simona SeizovaSchool of Life Sciences, The University of Dundee, Dundee, UK.ORCID 0000-0002-3703-4824
Abel FerrelDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0009-0003-0461-1335
John BoothroydDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. john.boothroyd@stanford.edu.ORCID 0000-0001-9719-745X
Christopher J TonkinThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. tonkin@wehi.edu.au.ORCID 0000-0002-7036-6222
Stanford University · USUniversity of Dundee · GBWalter and Eliza Hall Institute of Medical Research · AU

Funding

Department of Health | National Health and Medical Research Council (NHMRC) GNT2012271Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01AI172823NIH Training Grant T32U.S. Department of Health & Human Services | National Institutes of Health (NIH) RO1 AI129529
6 · The paper itself

Abstract

Toxoplasma gondii is a single-celled eukaryotic parasite with a considerable host range that must invade the cells of warm-blooded hosts to survive and replicate. The challenges and opportunities that such a strategy represent have been met by the evolution of effectors that are delivered into host cells, counter host defences and co-opt host cell functions for their own purposes. These effectors are delivered in two waves using distinct machinery for each. In this Review, we focus on understanding the architecture of these protein-export systems and how their protein cargo is recognized and selected. We discuss the recent findings on the role that host manipulation has in latent Toxoplasma infections. We also discuss how these recent findings compare to protein export in the related Plasmodium spp. (the causative agent of malaria) and how this can inform our understanding of host manipulation in the larger Apicomplexa phylum and its evolution.

Indexed as

PlasmodiumToxoplasmaCells, CulturedProtozoan ProteinsVacuolesProtozoan Proteins

Identifiers

PMID38172621
OpenAlexW4390544450

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.