Evidence map›Paper›PMID 38173207›Full record

ReviewCurrent topics in medicinal chemistry2024

Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis.

Xinwen Zhang, Jiamin Jin, Jiacheng Cong, Siqi Chen, Ting Wang, Bin Gao, Guanlin Huang, Zhiqiang Huang, Juzheng Zhang, Zhenran Wang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Xinwen ZhangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Jiamin JinKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Jiacheng CongKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Siqi ChenKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Ting WangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Bin GaoKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Guanlin HuangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Zhiqiang HuangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Juzheng ZhangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Zhenran WangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Jinfeng YangKey Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.
Guilin Medical University · CN

Funding

Guangxi Teachers Education University YCSW2023416Guangxi Zhuang Autonomous Region Health and Family Planning Commission 203030302315,203030302016National Natural Science Foundation of China 82100234,32360170,82260602,82060034National Natural Science Foundation of China 82260602,82060034,82100234,32360170Natural Science Foundation of Guangxi Province 2023GXNSFBA026313,2020GXNSFBA297004,2023GXNSFAA026061
6 · The paper itself

Abstract

Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional and post-translational regulation, ubiquitination plays an important role in the regulation of key proteins. There is a possibility that altered biological processes may lead to serious human diseases, including cancer. Recent studies have revealed the role of USPs in hepatocellular carcinoma tumorigenesis. The purpose of this review is to summarize the involvement of this class of enzymes in the regulation of cell signaling in hepatocellular carcinoma and the therapeutic development of inhibitors that target USPs, which may lead to novel therapies to treat hepatocellular carcinoma.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsUbiquitin-Specific ProteasesAnimalsAntineoplastic AgentsHumansSignal TransductionUbiquitinationAntineoplastic AgentsUbiquitin-Specific ProteasesDeubiquitinasesHepatocellular carcinomaPost-translational proteinsTumorigenesis.Ubiquitin-specific peptidasesUSP inhibitors

Identifiers

PMID38173207
OpenAlexW4390584988

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.