ArticleWorld journal of gastrointestinal oncology2023
Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients.
Article in World journal of gastrointestinal oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- New perspectives in prognostication of hepatocellular carcinoma: The role and clinical implications of transient receptor potential family genes.World journal of gastrointestinal oncology · 2024Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundMembers of the transient receptor potential (TRP) protein family shape oncogenic development, but the specific relevance of TRP-related genes in hepatocellular carcinoma (HCC) has yet to be defined.
aimTo investigate the role of TRP genes in HCC, their association with HCC development and treatment was examined.
methodsHCC patient gene expression and clinical data were downloaded from The Cancer Genome Atlas database, and univariate and least absolute shrinkage and selection operator Cox regression models were employed to explore the TRP-related risk spectrum. Based on these analyses, clinically relevant TRP family genes were selected, and the association between the key TRP canonical type 1 (TRPC1) gene and HCC patient prognosis was evaluated.
resultsIn total, 28 TRP family genes were screened for clinical relevance, with multivariate analyses ultimately revealing three of these genes (TRPC1, TRP cation channel subfamily M member 2, and TRP cation channel subfamily M member 6) to be significantly associated with HCC patient prognosis (
conclusionThese three TRP genes help determine HCC patient prognosis, providing insight into tumor immune status and immunological composition. These findings will help design combination therapies including immunotherapeutic and anti-TRP agents.
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