Evidence map›Paper›PMID 38173972›Full record

ArticleAIMS microbiology2023

Activation of cryptic biosynthetic gene clusters by fungal artificial chromosomes to produce novel secondary metabolites.

Chengcang C Wu, Andrea A Stierle, Donald B Stierle, Hongyu Chen, Michael Swyers, Timothy Decker, Emili Borkowski, Peter Korajczyk, Rosa Ye, Niel Mondava

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIMS microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chengcang C WuIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Andrea A StierleDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, USA.
Donald B StierleDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, USA.
Hongyu ChenIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Michael SwyersIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Timothy DeckerIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Emili BorkowskiIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Peter KorajczykIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Rosa YeIntact Genomics, Inc. 1100 Corporate Square Drive, Suite 257, St Louis, Missouri, 63132, USA.
Niel MondavaDepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812, USA.
Intact Genomics (United States) · USUniversity of Montana · US

Funding

Rapid dissection of the biosynthesis of antiMRSA antibiotics produced in co-culture by extremophilic fungi through the development of Fungal Artificial ChromosomesR43AI138765 · NIAID · INTACT GENOMICS, INC. · PI WU, CHENGCANG CHARLES · 2018 to 2018
$229k
NIAID NIH HHS R43 AI138765
6 · The paper itself

Abstract

In 2017, we reported the discovery of Berkeleylactone A (BPLA), a novel, potent antibiotic produced exclusively in co-culture by two extremophilic fungi,

Indexed as

cryptic biosynthesisFungal artificial chromosomeLiquid Chromatography/Mass Spectrometry (LC/MS)next-gen-sequencingNuclear Magnetic Resonance (NMR)secondary metabolites

Identifiers

PMID38173972
PMCPMC10758572
OpenAlexW4390011866

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.