Evidence map›Paper›PMID 38174372›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Impaired cardiopulmonary baroreflex function and altered cardiovascular responses to hypovolemia in patients with heart failure with preserved ejection fraction.

Jeremy K Alpenglow, Kanokwan Bunsawat, Michael A Francisco, Jesse C Craig, Jarred J Iacovelli, John J Ryan, D Walter Wray

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jeremy K AlpenglowDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-9769-4966
Kanokwan BunsawatDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-5950-6634
Michael A FranciscoDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0003-3392-4245
Jesse C CraigDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-5959-4139
Jarred J IacovelliDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0009-0007-2335-453X
John J RyanDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
D Walter WrayDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-6907-1734
University of Utah · US

Funding

Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Novel Approaches for Improving Vascular Function in Veterans with HFpEFI01CX002152 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI D. Walter Wray · 2021 to 2026
–
Efficacy of exercise training in patients with HFpEFI01RX003343 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI MARKUS AMANN · 2021 to 2026
–
Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans with Heart Failure with Preserved Ejection Fraction: Efficacy of Knee Extensor TrainingIK2RX003670 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI Kanokwan Bunsawat · 2022 to 2026
–
CSRD VA I01 CX002152NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007NHLBI NIH HHS T32 HL139451RRD VA I01 RX003343RRD VA IK2 RX003670
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is associated with autonomic dysregulation, which may be related to baroreflex dysfunction. Thus, we tested the hypothesis that cardiac and peripheral vascular responses to baroreflex activation via lower-body negative pressure (LBNP; -10, -20, -30, -40 mmHg) would be diminished in patients with HFpEF (

Indexed as

Heart FailureArteriesBaroreflexHumansHypovolemiaStroke Volumebaroreflexheart failurehypovolemiasympathetic nervous system

Identifiers

PMID38174372
PMCPMC11212821
OpenAlexW4390587514

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.