ArticleNature genetics2024
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
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Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 7 of them syntheses that pooled it.
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120citing papers in PubMed, 7 pooled it
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Who cites it
120 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.Functional & integrative genomics · 2026Pooled it
- Multiancestry and Multitrait GWAS Meta-Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases.Genes, brain, and behavior · 2026Pooled it
- Multi-Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome-Wide Association Meta-Analyses, Machine Learning, and Drug Repurposing Study.Brain and behavior · 2026Pooled it
- Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses.Translational psychiatry · 2025Pooled it
- Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression.Molecular psychiatry · 2025Pooled it
- Pooled it
- Identification of risk loci for postpartum depression in a genome-wide association study.Psychiatry and clinical neurosciences · 2024Pooled it
- Cross-ancestry pleiotropic analysis of imaging-derived phenotypes enhances risk stratification of depression.Molecular psychiatry · 2026Article
- Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.Molecular psychiatry · 2026Article
- Shared genetic architecture across social disconnection, social disadvantage, and psychiatric and neurodevelopmental traits.European archives of psychiatry and clinical neuroscience · 2026Article
- Assessing and refining a metabolite-based distress score for use in different populations within three US cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program.medRxiv : the preprint server for health sciences · 2026Article
- Cellular transcriptomic signatures underpinning the heterogeneity of depression in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder.Translational psychiatry · 2026Article
- BMI-genome interactions regulate global gene expression with emphasis in brain and gut.Cell genomics · 2026Article
- Multi-ancestry gene expression models amplify transcriptome-wide association study discovery and validation.Nature communications · 2026Article
- Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders.Molecular psychiatry · 2026Article
- A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.Molecular psychiatry · 2026Article
- Peripheral immune-redox signatures associate with cortical network alterations in anhedonic depression.Molecular psychiatry · 2026Article
- Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders.Molecular psychiatry · 2026Article
60 more citing papers are in PubMed but not listed here.
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Authors and funding
83 authors.
Xiangrui Meng *Division of Psychiatry, UCL, London, UK.ORCID http://orcid.org/0000-0003-4889-4640
Georgina Navoly *UCL Genetics Institute, UCL, London, UK.
Olga Giannakopoulou *Division of Psychiatry, UCL, London, UK.
Daniel F LeveyDepartment of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.ORCID http://orcid.org/0000-0001-8431-9569
Dora KollerDepartment of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-0415-0466
Gita A PathakDepartment of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.
Nastassja KoenSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Mark J AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
Miguel E RenteríaDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4626-7248
Yanzhe FengDivision of Psychiatry, UCL, London, UK.
J Michael GazianoDepartment of Medicine, VA Boston Healthcare System, Boston, MA, USA.
Dan J SteinSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Heather J ZarSAMRC Unit on Child and Adolescent Health, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Megan L CampbellDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-9481-3747
David A van HeelBlizard Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0637-2265
Bhavi TrivediBlizard Institute, Queen Mary University of London, London, UK.
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2684-4653
Andrew McQuillinDivision of Psychiatry, UCL, London, UK.ORCID http://orcid.org/0000-0003-1567-2240
Nick BassDivision of Psychiatry, UCL, London, UK.
V Kartik ChundruWellcome Sanger Institute, Saffron Walden, UK.ORCID http://orcid.org/0000-0002-6348-5565
Hilary C MartinWellcome Sanger Institute, Saffron Walden, UK.
Qin Qin HuangWellcome Sanger Institute, Saffron Walden, UK.ORCID http://orcid.org/0000-0003-3073-717X
Maria ValkovskayaDivision of Psychiatry, UCL, London, UK.
Chia-Yi ChuDivision of Psychiatry, UCL, London, UK.ORCID http://orcid.org/0009-0003-3050-4437
Susan KanjiraDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Po-Hsiu KuoDepartment of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-0365-3587
Hsi-Chung ChenDepartment of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-3191-0093
Shih-Jen TsaiInstitute of Brain Science and Division of Psychiatry, National Yang-Ming Chiao Tung University, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-9987-022X
Yu-Li LiuCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan.
Kenneth S KendlerDepartment of Psychiatry, VCU, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-8689-6570
Roseann E PetersonDepartment of Psychiatry, VCU, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-6402-849X
Na CaiHelmholtz Pioneer Campus, Helmholtz Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-7496-2075
Yu FangMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2810-806X
Srijan SenMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Laura J ScottDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4886-5084
Margit BurmeisterMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1914-2434
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Michael H PreussCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5266-8465
Ky'Era V ActkinsDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lea K DavisDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Monica UddinCollege of Public Health, University of South Florida, Tampa, FL, USA.
Agaz H WaniCollege of Public Health, University of South Florida, Tampa, FL, USA.
Derek E WildmanGenomics Program, College of Public Health, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6374-5136
Allison E AielloRobert N. Butler Columbia Aging Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Robert J UrsanoDepartment of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1861-9173
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4831-2305
Masahiro KanaiDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0001-5165-4408
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Saori SakaueDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID http://orcid.org/0000-0003-3618-9717
Jill A RabinowitzDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Brion S MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9809-0064
George UhlNeurology and Pharmacology, University of Maryland, Maryland VA Healthcare System, Baltimore, MD, USA.
William EatonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Carlos S Cruz-FuentesDepartamento de Genética, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9586-4052
Gabriela A Martinez-LevyDepartamento de Genética, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', Mexico City, Mexico.ORCID http://orcid.org/0000-0003-1736-5308
Adrian I CamposDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-3468-8619
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0807-0682
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-5873-7089
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-5447-4653
Yunxuan JiangDepartment of Biostatistics, Emory University, Atlanta, GA, USA.
Chao Tian23andMe, Inc., Mountain View, CA, USA.
Nicholas G MartinMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Brittany L MitchellMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9491-7797
Swapnil AwasthiStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jonathan R I ColemanSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Stephan RipkeStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3622-835X
PGC-MDD Working Group
China Kadoorie Biobank Collaborative Group
23andMe Research Team
Genes and Health Research Team
BioBank Japan Project
Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8520-8860
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9179-0321
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Renato PolimantiDepartment of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.ORCID http://orcid.org/0000-0003-0745-6046
Erin C DunnDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Murray B SteinDepartment of Psychiatry, UC San Diego School of Medicine, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Joel GelernterDepartment of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Cathryn M LewisSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8249-8476
Karoline KuchenbaeckerDivision of Psychiatry, UCL, London, UK. k.kuchenbaecker@ucl.ac.uk.ORCID http://orcid.org/0000-0001-9726-603X
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MPharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4MUnderstanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MThe Genetic Epemiology of Multiple SclerosisR01NS032830 · NINDS · VANDERBILT UNIVERSITY · PI HAINES, JONATHAN L · 1995 to 2010
$8.9MEpidemiologic Architecture for Genes Linked to Environment (EAGLE)U01HG004798 · NHGRI · VANDERBILT UNIVERSITY · PI CRAWFORD, DANA C · 2008 to 2013
$8.8MRESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2MChildhood adversity, DNA methylation, and risk for depression: A longitudinal study of sensitive periods in developmentR01MH113930 · NIMH · PURDUE UNIVERSITY · PI Erin Cathleen Dunn · 2017 to 2026
$6.6MVESPA: Vanderbilt Electronic Systems for Pharmacogenomic AssessmentRC2GM092618 · NIGMS · VANDERBILT UNIVERSITY · PI DENNY, JOSHUA C., RODEN, DAN M · 2009 to 2010
$6.4MBiotechnology and Biological Sciences Research Council BB/R01356X/1CSRD VA I01 CX001849Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2Medical Research Council MR/W014386/1NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS U19 HL065962NICHD NIH HHS P50 HD103537NICHD NIH HHS R01 HD074711NIDA NIH HHS R01 DA009897NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIMHD NIH HHS R01 MD011728NIMH NIH HHS R01 MH100549NIMH NIH HHS R01 MH101459NIMH NIH HHS R01 MH113930NIMH NIH HHS R01 MH124873NIMH NIH HHS R01 MH125938NIMH NIH HHS R21 MH126358NIMH NIH HHS T32 MH014276NINDS NIH HHS R01 NS032830Wellcome Trust 210561/Z/18/ZWellcome Trust 212946/Z/18/Z
Abstract
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS identified 53 significantly associated novel loci. For loci from GWAS in European ancestry samples, fewer than expected were transferable to other ancestry groups. Fine mapping benefited from additional sample diversity. A transcriptome-wide association study identified 205 significantly associated novel genes. These findings suggest that, for MD, increasing ancestral and global diversity in genetic studies may be particularly important to ensure discovery of core genes and inform about transferability of findings.
Indexed as
Genome-Wide Association StudyMajor Depressive DisorderChromosome MappingDepressionGenetic Predisposition to DiseaseHumansPolymorphism, Single Nucleotide
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