Evidence map›Paper›PMID 38178681›Full record

ArticleCombinatorial chemistry & high throughput screening2024

Acupuncture Combined with Bushen-Jianpi Decoction Ameliorates the Ovarian Function of Diminished Ovarian Reserve Rats by Regulating Phosphoinositide 3-Kinase/AKT Signaling.

Jianting Lao, Panwei Hu, Jia Li, Jiahui Li, Xiaole Zhang, Hong Yang, Cong Qi

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jianting LaoDepartment of Gynaecology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai, 200071, China.ORCID 0009-0002-2464-1104
Panwei HuDepartment of Gynaecology, Shanghai Shuguang Hospital, Shanghai, 200071, China.ORCID 0000-0002-2101-0481
Jia LiDepartment of Gynaecology, Shanghai Shuguang Hospital, Shanghai, 200071, China.ORCID 0009-0004-4880-7986
Jiahui LiDepartment of Gynaecology, Shanghai Shuguang Hospital, Shanghai, 200071, China.ORCID 0009-0008-9565-7967
Xiaole ZhangDepartment of Gynaecology, Shanghai Shuguang Hospital, Shanghai, 200071, China.ORCID 0000-0002-7185-1633
Hong YangDepartment of Gynaecology, Shanghai Hospital of Traditional Chinese Medicine, Shanghai, 200071, China.ORCID 0000-0001-9805-8718
Cong QiDepartment of Gynaecology, Shanghai Shuguang Hospital, Shanghai, 200071, China.ORCID 0009-0004-4906-4360
Shanghai University of Traditional Chinese Medicine · CNShanghai Traditional Chinese Medicine Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to explore the therapeutic efficiency as well as mechanism of acupuncture combined with Bushen-Jianpi decoction (BJD) to treat rats with diminished ovarian reserve (DOR).

methodsA DOR rat model was constructed using zona pellucida 3 peptide, and acupuncture, BJD, and their combination were administered as therapeutic interventions. We measured changes in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT, and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper 17 (Th17), Tc17, regulatory T (Treg), CD4

resultsAcupuncture combined with BJD induced a decrease in the levels of follicle-stimulating and luteinizing hormones, and the effect was greater than that elicited by BJD or acupuncture alone (P < 0.05). Additionally, this combination treatment effectively abrogated the increase in the levels of interleukin-2 (IL-2), IL-17, anti-zona pellucida antibody, and cleaved caspase-3 (P < 0.05), while promoting the regulation of IL-6 and p-AKT (P < 0.01). Furthermore, treatment with acupuncture combined with BJD restored the proportions of CD4

conclusionCombining acupuncture with BJD can enhance ovarian function in DOR rats. The regulation of sex hormone levels and immune function in rats may be attributed to the adjustment of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway, which leads to an improvement in the immune function of DOR rats.

Indexed as

Drugs, Chinese HerbalOvarian ReserveProto-Oncogene Proteins c-aktSignal TransductionAcupuncture TherapyAnimalsFemaleOvaryPhosphatidylinositol 3-KinasesRatsRats, Sprague-DawleyBushen formulaDrugs, Chinese HerbalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAcupuncturebushen-Jianpi decoctiondiminished ovarian reserveimmune mechanismphosphoinositide 3-kinase/AKT signaling.PI3K/AKT signaling pathway

Identifiers

PMID38178681
OpenAlexW4390609510

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.