Evidence map›Paper›PMID 38178910›Full record

ArticleFrontiers in molecular neuroscience2023

Genome-scale copy number variant analysis in schizophrenia patients and controls from South India.

Minali Singh, Dibyabhabha Pradhan, Poornima Kkani, Gundugurti Prasad Rao, Naveen Kumar Dhagudu, Lov Kumar, Chellamuthu Ramasubramanian, Srinivasan Ganesh Kumar, Surekha Sonttineni, Kommu Naga Mohan

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In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Minali SinghMolecular Biology and Genetics Laboratory, Department of Biological Sciences, Birla Institute of Technology and Science, Pilani - Hyderabad Campus, Hyderabad, India.
Dibyabhabha PradhanCentralized Core Research Facility, All India Institute of Medical Sciences, New Delhi, India.
Poornima KkaniDepartment of Zoology, Thiagarajar College, Madurai, India.
Gundugurti Prasad RaoAsha Hospital Institute of Medical Psychology, Hyderabad, India.
Naveen Kumar DhaguduESIC Medical College and Hospital, Hyderabad, India.
Lov KumarDepartment of Computer Engineering, National Institute of Technology, Kurukshetra, India.
Chellamuthu RamasubramanianDepartment of Psychiatry, M.S. Chellamuthu Trust and Research Foundation, Madurai, India.
Srinivasan Ganesh KumarDepartment of Psychiatry, M.S. Chellamuthu Trust and Research Foundation, Madurai, India.
Surekha SonttineniAsha Hospital Institute of Medical Psychology, Hyderabad, India.
Kommu Naga MohanMolecular Biology and Genetics Laboratory, Department of Biological Sciences, Birla Institute of Technology and Science, Pilani - Hyderabad Campus, Hyderabad, India.
Asha Hospital · INAll India Institute of Medical Sciences · INBirla Institute of Technology and Science - Hyderabad Campus · INBirla Institute of Technology and Science, Pilani · INNational Institute of Technology Kurukshetra · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copy number variants (CNVs) are among the main genetic factors identified in schizophrenia (SZ) through genome-scale studies conducted mostly in Caucasian populations. However, to date, there have been no genome-scale CNV reports on patients from India. To address this shortcoming, we generated, for the first time, genome-scale CNV data for 168 SZ patients and 168 controls from South India. In total, 63 different CNVs were identified in 56 patients and 46 controls with a significantly higher proportion of medium-sized deletions (100 kb-1 Mb) after multiple testing (FDR = 2.7E-4) in patients. Of these, 13 CNVs were previously reported; however, when searched against GWAS, transcriptome, exome, and DNA methylation studies, another 17 CNVs with candidate genes were identified. Of the total 30 CNVs, 28 were present in 38 patients and 12 in 27 controls, indicating a significantly higher representation in the former (

Indexed as

case–control studiesCNVsdeletionsduplicationsIndiaPsychArrayschizophrenia

Identifiers

PMID38178910
PMCPMC10764592
OpenAlexW4390056600

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.