Evidence map›Paper›PMID 38180449›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit.

Michael Freeman, Eline Huethorst, Erin Boland, Michael Dunne, Francis Burton, Chris Denning, Rachel Myles, Godfrey Smith

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael FreemanSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.
Eline HuethorstSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.ORCID 0000-0003-1900-4039
Erin BolandSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.
Michael DunneSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.
Francis BurtonSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.ORCID 0000-0002-6970-6250
Chris DenningBiodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0003-0802-8617
Rachel MylesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.ORCID 0000-0003-4670-361X
Godfrey SmithSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, United Kingdom.ORCID 0000-0003-4821-9741
University of Glasgow · GBUniversity of Nottingham · GB

Funding

British Heart Foundation SP/15/9/31605National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013202/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/T2T0119
6 · The paper itself

Abstract

Arrhythmic sudden cardiac death (SCD) is an important cause of mortality following myocardial infarction (MI). The rabbit has similar cardiac electrophysiology to humans and is therefore an important small animal model to study post-MI arrhythmias. The established approach of surgical coronary ligation results in thoracic adhesions that impede epicardial electrophysiological studies. Adhesions are absent following a percutaneously induced MI, which is also associated with reduced surgical morbidity and so represents a clear refinement of the approach. Percutaneous procedures have previously been described in large rabbits (3.5-5.5 kg). Here, we describe a novel method of percutaneous MI induction in smaller rabbits (2.5-3.5 kg) that are readily available commercially. New Zealand White rabbits (

Indexed as

Cardiac Surgical ProceduresCoronary OcclusionMyocardial InfarctionPercutaneous Coronary InterventionAnimalsArrhythmias, CardiacCoronary VesselsHeartHumansMaleRabbitsSwinecardiovascular diseaseclosed-chest modelintracoronary occlusionmyocardial infarctionpercutaneous surgery

Identifiers

PMID38180449
PMCPMC11221806
OpenAlexW4390618869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.