Evidence map›Paper›PMID 38181737›Full record

ArticleCell2024

XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells.

Iris Dror, Tsotne Chitiashvili, Shawn Y X Tan, Clara T Cano, Anna Sahakyan, Yolanda Markaki, Constantinos Chronis, Amanda J Collier, Weixian Deng, Guohao Liang and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 59 citations in OpenAlex.

  1. FASEB bioAdvances · 2026
    Article
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  7. Article
  8. Review
  9. Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026
    Review
  10. Remodeling ofScience advances · 2026
    Article
  11. Article
  12. Xist in X chromosome inactivation: mechanisms and disease relevance.Cell communication and signaling : CCS · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Genome research · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Iris DrorDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tsotne ChitiashviliDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shawn Y X TanDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Clara T CanoDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anna SahakyanDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yolanda MarkakiDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Institute for Structural and Chemical Biology & Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.
Constantinos ChronisDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Amanda J CollierDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Weixian DengDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Guohao LiangDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.
Yu SunDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anna AfasizhevaDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jarrett MillerDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Wen XiaoDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Douglas L BlackDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Fangyuan DingDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA.
Kathrin PlathDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of California, Irvine · USUniversity of Leicester · GB

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2022 to 2026
$14.0M
Universally-applicable RNA mapping at subcellular and single-base resolutionDP2GM149554 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DING, FANGYUAN · 2022 to 2025
$2.3M
Epigenetic control of the human X chromosomeR01HD098387 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PLATH, KATHRIN · 2019 to 2023
$2.2M
Establishing an imaging methodology to study developmentally-regulated chromatin changes during X-chromosome InactivationR03HD095086 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARKAKI, GIOLANTA · 2018 to 2019
$156k
Deciphering the role of XACT lncRNA in human developmentF30HD102190 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AFASIZHEVA, ANNA · 2020 to 2022
$127k
Mechanisms of XIST RNA-induced gene silencing in humansF31GM115122 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHAKYAN, ANNA · 2015 to 2016
$70k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS P01 HL160469NICHD NIH HHS F30 HD102190NICHD NIH HHS R01 HD098387NICHD NIH HHS R03 HD095086NIGMS NIH HHS DP2 GM149554NIGMS NIH HHS F31 GM115122NIGMS NIH HHS T32 GM007185NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of gene expression, wherein the long non-coding RNA XIST spreads across the X chromosome in cis to mediate gene silencing chromosome-wide. In female naive human pluripotent stem cells (hPSCs), XIST is in a dispersed configuration, and XCI does not occur, raising questions about XIST's function. We found that XIST spreads across the X chromosome and induces dampening of X-linked gene expression in naive hPSCs. Surprisingly, XIST also targets specific autosomal regions, where it induces repressive chromatin changes and gene expression dampening. Thereby, XIST equalizes X-linked gene dosage between male and female cells while inducing differences in autosomes. The dispersed Xist configuration and autosomal localization also occur transiently during XCI initiation in mouse PSCs. Together, our study identifies XIST as the regulator of X chromosome dampening, uncovers an evolutionarily conserved trans-acting role of XIST/Xist, and reveals a correlation between XIST/Xist dispersal and autosomal targeting.

Indexed as

Genes, X-LinkedRNA, Long NoncodingX ChromosomeAnimalsFemaleGene SilencingHumansMaleMicePluripotent Stem CellsRNA, Long Noncodingdispersed localizationdosage compensationhuman pluripotent stem cellslncRNApolycomb-repressive complexessexual dimorphismtrans-actingX chromosome dampeningX chromosome inactivationXIST

Identifiers

PMID38181737
PMCPMC10783549
OpenAlexW4390589459

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.