Bioinformatic analysis reveals the clinical value of SASH3 in survival prognosis and immune infiltration of acute myelocytic leukemia (AML).

Yufei Li, Lin Wang, Xueyuan Jia, Yanru Yang, Zhengqi Qiu

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Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yufei LiFaculty of Medicine, Macau University of Science and Technology Room PP-R203, Est. Seak Pai Van Praia Park, Rés-Do-Chão R, Coloane, Macau 999078, China.

Lin WangFaculty of Medicine, Macau University of Science and Technology Room PP-R203, Est. Seak Pai Van Praia Park, Rés-Do-Chão R, Coloane, Macau 999078, China.

Xueyuan JiaFaculty of Medicine, Macau University of Science and Technology Room PP-R203, Est. Seak Pai Van Praia Park, Rés-Do-Chão R, Coloane, Macau 999078, China.

Yanru YangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Shenzhen University Shenzhen 518060, Guangdong, China.

Zhengqi QiuFaculty of Medicine, Macau University of Science and Technology Room PP-R203, Est. Seak Pai Van Praia Park, Rés-Do-Chão R, Coloane, Macau 999078, China.

Macau University of Science and Technology · MOShenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML), a malignant clonal disease, is the most prevalent form of leukemia, and it is associated with a poor prognosis and unfavorable treatment outcomes in both pediatric and adult populations. Accordingly, enhancing anti-tumor responses using immunomodulators is a promising therapeutic strategy and a new avenue for treating AML. In this study, we used publicly available data from The Cancer Genome Atlas and Genotype-Tissue Expression databases to investigate the correlation between SAM and SH3 domain-containing 3 (SASH3) and AML, and we performed Cox regression and Kaplan-Meier analyses to assess the clinical characteristics associated with overall survival among patients with AML. Additionally, we analyzed the relationship between immune infiltration and SASH3. Compared with that in the normal group, patients with AML were characterized by significantly higher levels of SASH3 expression (

Indexed as

acute myeloid leukemiabioinformaticsprognosisSASH3TCGA

Identifiers

PMID38186980

PMCPMC10767538

OpenAlexW4390689706

What Socratic holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.