Evidence map›Paper›PMID 38190026›Full record

ArticleEndocrine2024

Mediation effect of antithrombin III between chronic renal insufficiency and chronic coronary artery disease in T2DM patients.

Ruoyu Sun, Jianhong Jia, Shaohua Wang, Zheng Wang, Chenchen Wang, Yanchao Xu, Yang Yuan

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ruoyu Sun *Department of Endocrinology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Jianhong Jia *Department of Endocrinology, Siyang Hospital of Traditional Chinese Medicine, Suqian, 223700, China.
Shaohua WangDepartment of Endocrinology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Zheng WangGansu Province Maternal and Child-Care Hospital, Lanzhou, 730050, China.
Chenchen WangDepartment of Endocrinology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China.
Yanchao XuCollege of Computer Science and Technology, Zhejiang University, Hangzhou, 310058, China.
Yang YuanDepartment of Endocrinology, The Affiliated Zhongda Hospital of Southeast University, Nanjing, 210009, China. zjxytg1111@163.com.ORCID 0009-0007-4781-1539
Zhongda Hospital Southeast University · CNAnyang Hospital of Traditional Chinese Medicine · CNGansu Provincial Maternal and Child Health Hospital · CNSoutheast University · BDZhejiang University · CN

Funding

National Natural Science Foundation of China No. 81870568, Shaohua Wang
6 · The paper itself

Abstract

purposeThe study aimed to investigate the potential effect of Antithrombin III (ATIII) between chronic renal insufficiency and chronic coronary artery disease (chronic CAD) in type 2 diabetes mellitus (T2DM) patients.

methodsT2DM patients hospitalized in ZhongDa Hospital from 2013 to 2018 were enrolled. Relationships between renal function, ATIII, and chronic CAD risk were explored using multivariate regression models. Multiplicative and additive interactions were investigated between ATIII and renal function for CAD risk, and the role of ATIII was determined by bootstrap mediation analysis in patients with chronic renal dysfunction.

resultsA total of 4197 patients were included in the study, with a chronic CAD prevalence of 23.02%. Low ATIII level was statistically associated with chronic renal insufficiency and elevated CAD risk even after adjustments (P < 0.05). A positive correlation between renal function and ATIII was demonstrated, and each 1 SD increase in renal function, ATIII increased by 2.947% (2.406-3.488%, P < 0.001) and 0.969% (0.297-1.642%, P < 0.001) in crude and adjusted models respectively. Patients with decreased renal function and ATIII were at the highest chronic CAD risk (OR = 1.51, 95%CI:1.15-1.98, P < 0.05), while no multiplicative and additive interaction effects were significant. Bootstrap mediation analysis estimated that ATIII mediated approximately 4.27% of the effect of chronic renal insufficiency on chronic CAD risk.

conclusionATIII may serve as a mediator between chronic renal insufficiency and chronic CAD, providing mechanistic clues for renal-heart association and new insight into clinical therapies.

Indexed as

Antithrombin IIICoronary Artery DiseaseDiabetes Mellitus, Type 2Renal Insufficiency, ChronicAgedFemaleHumansMaleMiddle AgedRisk FactorsAntithrombin IIIAntithrombin IIIChronic coronary artery diseaseChronic renal insufficiencyMediation analysisType 2 Diabetes Mellitus

Identifiers

PMID38190026
OpenAlexW4390672709

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.